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TPOSignalingPathway
Thrombopoietin (TPO) binds to its receptor inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several major pathways including MAPK (ERK and JNK), Protein Kinase C, and JAK/Stat.Contributor:REFERENCES:......阅读全文
血液肿瘤常用体内外模型总结&工具病毒使用指南
血液肿瘤主要包括各类白血病、多发性骨髓瘤以及恶性淋巴瘤。急性白血病占常见恶性肿瘤的第八位,淋巴瘤也是在前十位,并且发病率逐年升高,多发性骨髓瘤的整个发病率在血液恶性肿瘤里面占10%。 血液肿瘤发病急,在传统的放疗、化疗、骨髓移植等治疗方式下,治疗周期长、费用高昂、过程痛苦,但治愈率却并不很
PTEN dependent cell cycle arrest and apoptosis
PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of
T Helper Cell Surface Molecules
T helper cells play an essential role coordinating the activities of other parts of the immune system, including B cells, cytotoxic T cells, macrophag
Cells and Molecules involved in local acute inflammatory response
Inflammation has several distinct components, including the localized response at the site of tissue injury or infection. Tissue injury stimulates the
A Method for Structure-1
A Method for Structure–Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable StreptococciMany species of streptococci se
BCR Signaling Pathway
Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observa
Activation of cAMP-dependent protein kinase, PKA
G-protein coupled receptors (GPCRs) are one of the largest gene families of signaling proteins. Residing in the plasma membrane with seven transmembra
Signaling of Hepatocyte Growth Factor Receptor
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
NFAT and Hypertrophy of the heart (Transcription in the broken heart)
Hypertrophy associated with both hypertension and obstruction to ventricular outflow leads to pathologic cardiac growth and it is associated with incr
王萌团队新成果登《Cell》:细菌的特定基因,既延寿又安康
肠道微生物对健康的影响已经毋庸置疑。随着研究的深入,科学家们发现这些潜伏于宿主体内的“附加器官”与延缓衰老、延长寿命有关联。但是,具体哪些细菌基因、细菌代谢产物可以延年益寿呢?一直未有定论。 当地时间6月15日,来自于美国贝勒医学院王萌教授团队在《Cell》期刊发表了一篇题为“Microbia
Med64关于胰岛素对幼鼠海马LTP表达的研究
Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats 胰岛素对幼鼠海马长时程增强(LTP)表达的促进作用Prof Yung WH
Role of PPAR-gamma Coactivators in Obesity and Thermogenesis
Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPAR-gamma is a member of t
动物所等Wip1调控中性粒细胞发育分化研究获进展
中性粒细胞在机体抗感染防御及自身损伤中均发挥重要作用。因此,维持中性粒细胞适度的内稳态具有十分重要意义。野生型P53诱导的磷酸酶1(Wild type p53-induced phosphatase 1,Wip1 )由PPM1D(protein phosphatase magnesium-d
Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
Cyclin-dependent kinase inhibitor-2A (CDKN2A) goes by the colloquial designation p16, which is sometimes referred to as p16(INK4). The alpha transcrip
mTOR Signaling Pathway
mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate t
王萌团队新成果登《Cell》:细菌的特定基因,既延寿又安康
肠道微生物对健康的影响已经毋庸置疑。随着研究的深入,科学家们发现这些潜伏于宿主体内的“附加器官”与延缓衰老、延长寿命有关联。但是,具体哪些细菌基因、细菌代谢产物可以延年益寿呢?一直未有定论。 当地时间6月15日,来自于美国贝勒医学院王萌教授团队在《Cell》期刊发表了一篇题为“Microbia
VEGF, Hypoxia, and Angiogenesis
Vascular endothelial growth factor (VEGF) plays a key role in physiological blood vessel formation and pathological angiogenesis such as tumor growth
Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk netwo
Role of ERBB2 in Signal Transduction and Oncology
Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the
IGF-1 Signaling Pathway
Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many differen
Stress Induction of HSP Regulation
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
Regulation of ck1/cdk5 by type 1 glutamate receptors
Cdk5 is a cyclin dependent protein kinase involved in dopaminergic signaling in the neostriatal region of the brain. The role of cdk5 in dopamine resp
Rho-Selective Guanine Exchange FactorAKAP13 Mediates Stress Fiber Formation
The A-kinase anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of
EGF Signaling Pathway
The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kinase cytoplasmic domain, a s
基因芯片数据的分析方法
研究背景:基因芯片可以通过探针和荧光标记对某个时间点生物体的全部基因表达量进行检测,探针代表的基因荧光强度通过仪器转换成基本数据。这些数据的背后隐藏着很多的生物学意义,这就需要我们通过生物信息学的方法去分析和挖掘。不同实验设计方案产生的海量芯片数据,其分析方法和思路都大同小异,这里分享一个多组实验设
IL-7 Signal Transduction
IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T
基因芯片数据的分析方法
研究背景:基因芯片可以通过探针和荧光标记对某个时间点生物体的全部基因表达量进行检测,探针代表的基因荧光强度通过仪器转换成基本数据。这些数据的背后隐藏着很多的生物学意义,这就需要我们通过生物信息学的方法去分析和挖掘。不同实验设计方案产生的海量芯片数据,其分析方法和思路都大同小异,这里分享一个多组实验设
Human Cytomegalovirus and Map Kinase Pathways
To replicate in the host cell, viruses commandeer cellular signaling pathways. Cytomegalovirus (CMV) is a DNA virus with that is widespread in the pop
Induction of apoptosis through DR3 and DR4/5 Death Receptors
Apoptosis is specifically induced via signaling through a family of receptors known collectively as death receptors including Fas, TNFR, DR3
Multi-step Regulation of Transcription by Pitx2
Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated t
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