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TheBM8.1antibodyisspecificformouseF4/80antigen,a125kDatransmembraneproteinwidelyexpressedbymembersofthemononuclearphagocytesystemandconsideredtobeakeyMarkerformaturemacrophagecells.F4/80isdifferentiallyexpressedduringmyeloidcelldevelopment,andmayberegulatedbycertaincytokineswithinthetissuemicroenvironment.OthercelltypesshowntoexpressthisantigenincludeLangerhanscells,Kupffercellsanddendriticcellsubsets.BM8.1iswidelyusedtogetherwithantibodiestoCD115(c-fms),CD11bandCD11ctoidentifymyeloid/macrophagecellsbyflowcytometry.

RecentPublications:
WuJandWaxmanDJ.2015.OncoImmunol.DOI:10.1080/2162402X.2015.1005521.(FlowCytometry)

Name	APCAnti-MouseF4/80Antigen(BM8.1)
Cat.No.	20-4801
AlternativeNames	EMR1,Ly71
GeneID	13733
Clone	BM8.1
Isotype	RatIgG2b,κ
Reactivity	Mouse
CrossReactivity
Format	APC
Applications	FlowCytometry
Citations*	IoannouM,AlissafiT,BoonL,BoumpasD,andVerginisP.2013.J.Immunol.190:2631-2640.(FlowCytometry) PapadopoulosG,WeinbergEO,MassariP,GibsonFC,WetzlerLM,MorganEF,andGencoCA.2013.J.Immunol.190:1148-1157. ChenQandSnapperCM.2013.J.Immunol.190:1048-1055. RankinAL,MummJB,MurphyE,TurnerS,YuN,McClanahanTK,BournePA,PierceRH,KasteleinRandPflanzS.2010.J.Immunol.184(3):1526-1535.(Immunohistochemistry-paraffin-embeddedtissue) GeutskensSB,OtonkoskiT,PulkkinenMA,DrexhageHAandLeenenPJ.2005.J.Leukoc.Biol.78(4):845-52(Immunohistochemistry-frozentissue)

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