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Squeezing females for Eggs 发育生物学资讯

mayitao /发布时间:1630517402 /浏览量:581

The3G3antibodyreactswithmouseFoxp3,a50-55kDatranscriptionfactorwhichisacentralregulatorofTcellactivityandiscriticalforthedevelopmentandfunctionofregulatoryTcells(Tregs).Foxp3isexpressedatconstitutivelyhighlevelsinTregcells,whicharefurtheridentifiedasbeingCD4+CD25+.InrestingconventionalTcells(CD4+CD25-)Foxp3expressionisrestricted,anduponTCRactivationisexpressedonlytransientlyandinasmallproportionofcells.However,thegrowthfactorTGF-betahasbeenshowntoinduceexpressionofFoxp3innaïveTcells,drivingtheirdevelopmentintoFoxp3+Tregs,whicharecalled“induced”or“adaptive”Tregs.Thesecellsarephenotypicallysimilartoso-called“natural”Tregs(CD4+CD25highFoxp3+)whichoriginateinthethymusandcomprisethemajorityofTregcells.Tregsarecriticalformaintainingperipheraltoleranceandareimplicatedinthedevelopmentofautoimmunity.

ItisimportanttoreviewtheliteratureinchoosinganantibodyfortheFoxp3antigeninflowcytometry,asthepotentialforhighbackgroundornon-specificstainingmaybeobserved.The3G3antibodymaybeusedforintracellulardetectionofFoxp3incellsfrommouseandRhesusmacaque.

Name	APCAnti-MouseFoxp3(3G3)
Cat.No.	20-5773
AlternativeNames	ForkheadBoxP3,Scurfin
GeneID	50943/20371
Clone	3G3
Isotype	MouseIgG1,kappa
Reactivity	Mouse
CrossReactivity	Rhesusmacaque
Format	APC
Applications	FlowCytometry
Citations*	RamosRN,OliveiraCE,GasparotoTH,etal.2012.Carcinogenesis.33:902-909.(Flowcytometry) KleinM,VaethM,ScheelT,GrabbeS,BaumgrassR,Berberich-SiebeltF,BoppT,SchmittE,andBeckerC.2012.J.Immunol.188:1091-1097.(Flowcytometry) AnsariAA,ReimannKA,MayneAE,TakahashiY,StephensonST,WangR,WangX,LiJ,PriceAA,LittleDM,ZaidiM,LylesR,andVillingerF.2011.J.Immunol.186:1044-1059.(Flowcytometry–Rhesusmacaque) NagarM,VernitskyH,CohenY,DominissiniD,BerkunY,RechaviG,AmariglioN,andGoldsteinI.2008.Int.Immunol.20:1041-1055.(Flowcytometry) HombachAA,KoflerD,HombachA,RapplG,andAbkenH.2007.J.Immunol.179:7924-7931.(Flowcytometry). GavinMA,TorgersonTR,HoustonE,deRoosP,HoWY,Stray-PedersenA,OcheltreeEL,GreenbergPD,OchsHD,andRudenskyAY.2006.ProcNatlAcadSciUSA.103(17):6659-6664.(Flowcytometry)

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Squeezing females for Eggs 发育生物学 资讯

Squeezing females for Eggs 发育生物学资讯