抗猪

《猴年说“猴”》阅读答案 语文阅读网

The116-13.1monoclonalantibodyreactswithmouseCD8alsoknownasLyt-2.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCRCD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcellsbutcanalsobefoundonthymocytesnaturalkillercellsandsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhoweveritcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.The116-13.1antibodyexhibitsdepletingactivitywhenusedinvivo.

Isotype

MouseIgG2a

RecomendedIsotypeControl(s)InVivoMAbmouseIgG2aisotypecontrol,unknownspecificity
RecommendedInVivoPureDilutionBufferInVivoPurepH7.0DilutionBuffer
Immunogen

CEmousespleencellsandthymocytes

ReportedApplications
  • invivoCD8+Tcelldepletion
  • Flowcytometry
Endotoxin
  • <2EU/mg(<0.002EU/μg)
  • DeterminedbyLALgelclottingassay
Purity
  • >95%
  • DeterminedbySDS-PAGE
Formulation
  • PBS,pH7.0
  • Containsnostabilizersorpreservatives
Sterility

0.2μMfiltered

Production

Purifiedfromtissueculturesupernatantinananimalfreefacility

Purification

ProteinG

Storage

Undilutedat4°Cinthedark

References
SDSSheet

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