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蚂蚁淘在线 / 品牌中心 / Xcess / Xcessbio/WAY-316606，分泌型卷曲相关蛋白-1（sFRP-1）抑制剂-Xcessbio Biosciences Inc/2 mg固体/M60215-2s

Xcessbio/WAY-316606，分泌型卷曲相关蛋白-1（sFRP-1）抑制剂-Xcessbio Biosciences Inc/2 mg固体/M60215-2s

价格
￥2780.00
货号：M60215-2s
浏览量：85
品牌：Xcess
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Product Information
Molecular Weight:484.94
Formula:C18H19F3N2O4S2.HCl
Purity:≥98%
CAS#:423148-78-1
Solubility:DMSO up to 100 mM
Chemical Name: 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride
Storage:Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year.

Biological Activity:

WAY-316606 is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50~ 0.65 μM. It prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. WAY-316606 can increase total bone area in a murine calvarial organ culture assay.

How to Use:

  • In vitro: WAY-316606 was used at 1-10 µM final concentration in various in vitro assays.
  • In vivo:n/a

Reference:

  • 1. Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. (2009) Bone. 44(6):1063-8.
  • 2. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. (2009) J Med Chem. 52(1):105-16.
  • 3. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. (2010) Bioorg Med Chem. 18(1):190-201.

  • WAY-316606_spec.pdf
  • WAY-316606_MSDS.pdf

Products are for research use only. Not for human use.

Xcess生物科学公司(XcessBio)成立于2008年,由一群顶尖的科学家来自学术界和制药/生物技术产业具有较强的专业知识在药物化学、生物化学、分子和细胞生物学。