IL-10isacytokinewithpotentanti-inflammatoryproperties,repressingtheexpressionofinflammatorycytokinessuchasTNF-alpha,IL-6andIL-1byactivatedmacrophages.TheIL-10receptorisintheJAK/STATclassofreceptorsbutactivationoftheJAK/STATpathwaysbyIL-10doesnotappearonitsowntoberesponsIBLefortheanti-inflammatorypropertiesofthiscytokine.Theanti-inflammatoryactionsofIL-10appeartorequireinductionoftheenzymehemeoxygenase-1(HO-1)throughamapkinasepathwayinvolvingthep38kinases.HO-1isinvolvedinthebiosynthesisofheme,andcatalyzesareactionproducingcarbonmonoxide,freeiron,andthehemeprecursorbiliverdin.HO-1isinducedbyIL-10andisalsoinducedbyoxidativestress.BlockingHO-1withinhibitorsorantisenseblockstheanti-inflammatoryactionsofIL-10.Theanti-inflammatoryactionsofHO-1appeartobetheresultofsignalingbycarbonmonoxideitproducessinceremovalofCOblockstheanti-inflammatoryactionofIL-10andHO-1.Theanti-inflammatoryactionsofIL-10maybetherapeuticallyusefuleitherdirectlyorthroughmodulationofHO-1activity.

Contributor:GlennCroston,PhD.

REFERENCES:BerlatoC,CassatellaMA,KinjyoI,GattoL,YoshimuraA,BazzoniF.Involvementofsuppressorofcytokinesignaling-3asamediatoroftheinhibitoryeffectsofIL-10onlipopolysaccharide-inducedmacrophageactivation.JImmunol.2002Jun15;168(12):6404-11.LeeTS,ChauLY.Hemeoxygenase-1mediatestheanti-inflammatoryeffectofinterleukin-10inmice.NatMed.2002Mar;8(3):240-6.OFarrellAM,LiuY,MooreKW,MuiAL.IL-10inhibitsmacrophageactivationandproliferationbydistinctsignalingmechanisms:evidenceforStat3-dependentand-independentpathways.EMBOJ.1998Feb16;17(4):1006-18.OtterbeinLE,BachFH,AlamJ,SoaresM,TaoLuH,WyskM,DavisRJ,FlavellRA,ChoiAM.Carbonmonoxidehasanti-inflammatoryeffectsinvolvingthemitogen-activatedproteinkinasepathway.NatMed.2000Apr;6(4):422-8.RileyJK,TakedaK,AkiraS,SchreiberRD.Interleukin-10receptorsignalingthroughtheJAK-STATpathway.Requirementfortwodistinctreceptor-derivedsignalsforanti-inflammatoryaction.JBiolChem.1999Jun4;274(23):16513-21.

================  蚂蚁淘在线  ================

免责声明：本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容

版权声明：未经蚂蚁淘在线授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的，应该授权范围内使用，并注明“来源：蚂蚁淘在线”。违反上述声明者，本网将追究其相关法律责任。