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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/Ro 51/4391/10/10毫克

Tocris/Ro 51/4391/10/10毫克

价格
￥3980.00
货号：4391/10
浏览量：127
品牌：Tocris
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商品描述
Description: Potent P2X3, P2X2/3 antagonist
Chemical Name: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol
Purity: ≥98% (HPLC)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable.

Technical Data

M. Wt 474.29
Formula C17H23IN4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1050670-85-3
PubChem ID 24883277
InChI Key PAYROHWFGZADBR-UHFFFAOYSA-N
Smiles NC1=NC(NC(CO)CO)=NC=C1OC2=C(C(C)C)C=C(OC)C(I)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.43 100
ethanol 47.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 474.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Jahangir et al (2009) Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain. Bioorg.Med.Chem.Lett. 19 1632 PMID: 19231178

Syed and Kennedy (2012) Pharmacology of P2X receptors WIREs.Membr.Transp.Signal. 1 16 PMID:

Keywords: Ro 51, supplier, Ro51, Potent, selective, P2X3, P2X2/3, P2X, purinergic, receptors, antagonists, purinoceptors, P2X, Receptors, P2X, Receptors, Tocris Bioscience

我们的目的是通过提供全球范围内性能最高，最具创新性的研究试剂，使新的生命科学发现成为可能。 我们所做的 Tocris Bioscience是高性能生命科学试剂，肽和抗体的领先供应商，其客户几乎遍布全球所有主要的制药公司，大学和研究机构。该公司致力于通过提供最具创新性的高纯度产品来推动生命科学研究。我们的1,800多种试剂目录代表着独特的，新颖的，专有的和许可的研究工具，并且每年发送给全球50,000多名科学家。Tocris产品供科学家在癌症，心血管疾病，疼痛和感染等领域进行非临床研究时使用。