Eosinophilsareakeyclassofleukocytesinvolvedininflammatoryresponses,includingallergicreactionsinskinandairway.TheeosinophilresponseininflammationisabsentinmicelackingCCR3,indicatingthekeyroleofthisGproteincoupledreceptorininflammationandallergicresponses.EotaxinisachemokineligandforCCR3thatrecruitseosinophilstothesiteofinflammationandactivatesthem.OtherchemokineligandsofCCR3includeeotaxin-2,MCP-3,MCP-4,andRANTES.MultiplesignalingpathwaysactivatedbyCCR3participateintheinflammatoryresponseofeosinophils.Eotaxinstimulatesintracellularcalciumrelease,productionofreactiveoxygenspecies,andchangesinactinpolymerizationthroughapertussissensitivepathway.RhoandROCKregulateactinstressfiberformationandarerequiredforeosinophilchemotaxis.RhoisaGproteinthatactivatesROCK,aproteinkinase.Mapkinasepathwaysarealsoinvolvedinchemotaxis.Anotherkeyactionofactivatedeosinophilsisthereleaseofreactiveoxygenspecies,causingtissuedamageduringchronicinflammatoryresponses.Blockingeosinophilactivationandthesignalingpathwaysthatleadtochemotaxis,degranulationandreactiveoxygenreleasemayalleviateinflammatoryconditionsandinflammation-associatedtissuedamage.

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