凝血酶原片段1+2在不同血栓性疾病中的临床意义及研究进展相关交流-蚂蚁淘在线

凝血酶原片段1+2是凝血酶原激活转化为凝血酶过程中释放的稳定的降解产物，血液中的凝血酶原片段1+2含量可以准确地反映凝血酶早期激活水平，可用于诊断血栓前状态和血栓性疾病以及针对相关疾病及时治疗和监测疗效。

以人凝血酶原片段1+2为例，当凝血途径启动，凝血因子X被激活转变为Xa，Xa可促使凝血酶原中Arg(327)-Thr(328)及Arg(363)-Ile(364)间的肽键同时断裂，释放凝血酶及凝血酶原片段1+2，即Ala(44)-Arg(327)。该凝血酶能够裂解酶原本身，释放出片段1（F1）和片段2（F2），序列分别为Ala(44)-Arg(198)，Ser(199)-Arg(327)（见图1）。

凝血酶原片段1+2的研究已经从实验走向临床，Cloud-CloneCorp.针对此片段研制了一系列产品，对于实验室科研客户推出了引物对，重组蛋白，特异性抗体和免疫检测试剂盒等科研产品，工业级客户推出了抗体对以及DIY试剂盒产品，以及针对临床研究客户的IVD原料产品，产品列表如下，欢迎需求的客户咨询及选购。

	CATALOGNO.	ORGANISMSPECIES	PRODUCTNAME	APPLICATIONS
IncrementService	PGA710Hu01	Homosapiens(Human)	PrimerPairforProthrombinFragment1+2(F1+2)	PCR
	PGA710Mu01	Musmusculus(Mouse)	PrimerPairforProthrombinFragment1+2(F1+2)	PCR
	PGA710Ra01	Rattusnorvegicus(Rat)	PrimerPairforProthrombinFragment1+2(F1+2)	PCR
Proteins	RPA710Hu01	Homosapiens(Human)	RecombinantProthrombinFragment1+2(F1+2)	PositiveControl;Immunogen;SDS-PAGE;WB.
	RPA710Mu01	Musmusculus(Mouse)	RecombinantProthrombinFragment1+2(F1+2)	PositiveControl;Immunogen;SDS-PAGE;WB.
	RPA710Ra01	Rattusnorvegicus(Rat)	RecombinantProthrombinFragment1+2(F1+2)	PositiveControl;Immunogen;SDS-PAGE;WB.
Antibodies	PAA710Hu01	Homosapiens(Human)	PolyclonalAntibodytoProthrombinFragment1+2(F1+2)	WB;IHC;ICC;IP.
	LAA710Hu71	Homosapiens(Human)	Biotin-LinkedPolyclonalAntibodytoProthrombinFragment1+2(F1+2)	WB;IHC;ICC.
	MAA710Hu21	Homosapiens(Human)	MonoclonalAntibodytoProthrombinFragment1+2(F1+2)	WB;IHC;ICC;IP.
	LAA710Hu72	Homosapiens(Human)	Biotin-LinkedMonoclonalAntibodytoProthrombinFragment1+2(F1+2)	WB;IHC;ICC.
	PAA710Mu01	Musmusculus(Mouse)	PolyclonalAntibodytoProthrombinFragment1+2(F1+2)	WB;IHC;ICC;IP.
	PAA710Ra01	Rattusnorvegicus(Rat)	PolyclonalAntibodytoProthrombinFragment1+2(F1+2)	WB;IHC;ICC;IP.
	LAA710Ra81	Rattusnorvegicus(Rat)	FITC-LinkedPolyclonalAntibodytoProthrombinFragment1+2(F1+2)	WB;IHC;ICC;IF.
	LAA710Ra71	Rattusnorvegicus(Rat)	Biotin-LinkedPolyclonalAntibodytoProthrombinFragment1+2(F1+2)	WB;IHC;ICC.
AssayKits	SEA710Hu	Homosapiens(Human)	ELISAKitforProthrombinFragment1+2(F1+2)	Enzyme-linkedimmunosorbentassayforAntigenDetection.
	SCA710Hu	Homosapiens(Human)	CLIAKitforProthrombinFragment1+2(F1+2)	ChemiluminescentimmunoassayforAntigenDetection.
	HEA710Hu	Homosapiens(Human)	HighSensitiveELISAKitforProthrombinFragment1+2(F1+2)	Enzyme-linkedimmunosorbentassayforAntigenDetection.
	SEA710Mu	Musmusculus(Mouse)	ELISAKitforProthrombinFragment1+2(F1+2)	Enzyme-linkedimmunosorbentassayforAntigenDetection.
	SCA710Ra	Rattusnorvegicus(Rat)	CLIAKitforProthrombinFragment1+2(F1+2)	ChemiluminescentimmunoassayforAntigenDetection.
	SEA710Ra	Rattusnorvegicus(Rat)	ELISAKitforProthrombinFragment1+2(F1+2)	Enzyme-linkedimmunosorbentassayforAntigenDetection.
	SEA710Po	Susscrofa;Porcine(Pig)	ELISAKitforProthrombinFragment1+2(F1+2)	Enzyme-linkedimmunosorbentassayforAntigenDetection.
AntibodyPairs	PSA710Hu01	Homosapiens(Human)	AntibodyPairforTroponinIType1,SlowSkeletal(TNNI1)	ELISA;CLIA;ELISPOT;Luminex;ImmunochromatographyandotherImmunoassays.
	PSA710Mu01	Musmusculus(Mouse)	AntibodyPairforTroponinIType1,SlowSkeletal(TNNI1)	ELISA;CLIA;ELISPOT;Luminex;ImmunochromatographyandotherImmunoassays.
	PSA710Ra01	Rattusnorvegicus(Rat)	AntibodyPairforTroponinIType1,SlowSkeletal(TNNI1)	ELISA;CLIA;ELISPOT;Luminex;ImmunochromatographyandotherImmunoassays.
	PSA710Po01	Susscrofa;Porcine(Pig)	AntibodyPairforTroponinIType1,SlowSkeletal(TNNI1)	ELISA;CLIA;ELISPOT;Luminex;ImmunochromatographyandotherImmunoassays.
AssayKitDIYMaterials	KSA710Hu01	Homosapiens(Human)	ELISAKitDIYMaterialsforProthrombinFragment1+2(F1+2)	Mainmaterialsfor"DoIt(ELISAKit)Yourself"
	KSA710Mu01	Musmusculus(Mouse)	ELISAKitDIYMaterialsforProthrombinFragment1+2(F1+2)	Mainmaterialsfor"DoIt(ELISAKit)Yourself"
	KSA710Ra01	Rattusnorvegicus(Rat)	ELISAKitDIYMaterialsforProthrombinFragment1+2(F1+2)	Mainmaterialsfor"DoIt(ELISAKit)Yourself"
	KSA710Po01	Susscrofa;Porcine(Pig)	ELISAKitDIYMaterialsforProthrombinFragment1+2(F1+2)	Mainmaterialsfor"DoIt(ELISAKit)Yourself"
IVDRawMaterials	RSA710Hu21	Homosapiens(Human)	Anti-ProthrombinFragment1+2(F1+2)MonoclonalAntibodyforIVDRawMaterial	ELISA;WB;IHC;Other Immunoassays.
IVDRawMaterials	RSA710Hu01	Homosapiens(Human)	Anti-ProthrombinFragment1+2(F1+2)PolyclonalAntibodyforIVDRawMaterial	ELISA;WB;IHC;Other Immunoassays.

表1凝血酶原片段1+2系列产品

免责声明：本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容