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SK1快速混匀器(漩涡混合器)_价格_厂家_品牌
Clone/ABfeature:
(#6E1)Antibodygeneration:
Thisantibodywasproducedfromahybridoma(mousemyelomafusedwithspleencellsfromarat)immunizedwithrecombinantmouseEphA7extracellulardomain.IgG1fractionoftheculturesupernatantwaspurifiedbyProteinA/Gaffinitychromatography.Antigen:
RecombinantmouseEphA7extracellulardomainStability:
Lyophilizedsamplesarestablefor2yearsfromdateofreceiptwhenstoredat-70°C.Reconstitutedantibodycanbealiquotedandstoredfrozenat< -20 °C for at least for six months without detectable loss of activity.Reconstitution:
Reconstitutetheantibodywith500µlsterilePBSandthefinalconcentrationis200µg/ml.Description:
EphA7,alsoknownasMdk1,Hek11,Ehk3,Ebk,andCek11,isamemberoftheEphreceptorfamilywhichbindsmembersoftheephrinligandfamily.Therearetwoclassesofreceptors,designatedAandB.BoththeAandBclassreceptorshaveanextracellularregionconsistingofaglobulardomain,acysteinerichdomain,andtwofibronectintypeIIIdomains.Thisisfollowedbythetransmembraneregionandthecytoplasmicregion.Thecytoplasmicregioncontainsajuxtamembranemotifwithtwotyrosineresidues,whicharethemajorautophosphorylationsites,akinasedomain,andaconservedsterilealphamotif(SAM)inthecarboxytailwhichcontainsoneconservedtyrosineresidue.Activationofkinaseactivityoccursafterligandrecognitionandbinding.EphA7hasbeenshowntobindephrinA2,ephrinA3,ephrinA1,ephrinA4,andephrinA5.TheextracellulardomainsofhumanandmouseEphA7sharegreaterthan97%aminoacididentity.OnlymembraneboundorFc-clusteredligandsarecapableofactivatingthereceptorinvitro.Whilesolublemonomericligandsbindthereceptor,theydonotinducereceptorautophosphorylationandactivation.Invivo,theligandsandreceptorsdisplayreciprocalexpression.Ithasbeenfoundthatnearlyallreceptorsandligandsareexpressedindevelopingandadultneuraltissue.TheEph/ephrinfamiliesalsoappeartoplayaroleinangiogenesis.
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