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商品描述
| Source | M.W. | 482.19 | CAS No. | 391210-10-9 | |
|---|---|---|---|---|---|
| Structural Info | N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE | ||||
| Formulation | Powder | ||||
| Reconstitution | Before reconstitution, we recommend a brief spin todrive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO. | ||||
| Stability | The powder is stable for at least 2 year if stored at-20 °C. The dissolved compound isstable for at least 1 month at 4 °C, but should be stored in aliquots at-20 °C for longer term. Protectfrom light. | ||||
| Purity | Greater than 98% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request. | ||||
| Biological Activity | |||||
| Country of Origin | USA | ||||
A selective inhibitor against purified MEK,exhibiting a Ki of 1 nM against activated MEK1 and MEK2. It has been shown that 1 µM PD0325901 combined with 3 µM CHIR99021 (2i)prevents cell differentiation and sustains self-renewal of murine embryonicstem cells.N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDERef: Barret, S.D., Bridges, A.J., Dudley,D.T., et al. Thediscovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett 186501-6504, 2008.Ying, Q., Wray, J., Nichols, J., et al. The ground state ofembryonic stem cell self-renewal. Nature 453 519-524, 2008.
