Beta-TrCP plays a relevant role in the control of stability of several key protein factors. In Xenopus, beta-TrCP acts as an inhibitor of Wnt signaling and dorsal axis formation.

A variety of cellular stress can induce the level of beta-TrCP mRNA and protein levels in human cells. Activation of stress-activated protein kinases JNK by forced expression of constitutively active mutants of JNKK2 and MKK6 also leads to accumulation of beta-TrCP. Another role played by beta- TrCP is the targeting of Cdc25A for degradation by the Skp1/Cul1/F-box protein complex.