ICM11 (MW 90kD) is a member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines on T-lymphocytes, thymocytes, denritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells.

CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18m(Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.