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| MolecularWeight: | 405.47 |
| Formula: | C21H19N5O2S |
| Purity: | ≥98% |
| CAS#: | 331244-89-4 |
| Solubility: | DMSOupto100mM |
| ChemicalName: | (E)-4-(2-(2-ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one |
| Storage: | Powder:4oC1year.DMSO:4oC3month;-20oC1year. |
BIOLOGicalActivity:
BAM7isthefirstpotentandselectivesmallmoleculeactivatorofBAX,whichisapro-apoptoticBCL-2familymember.ItbindstheBAXtriggersitewithanEC50~3.3μMasmeasuredinacompetitiveFPassayusingFITC-BIMSAHBandBAX.BAM7triggersinvitroBAXoligomerization,BAX-mediatedporeformation,anddoesnotinteractwiththeBH3-bindingpocketofantiapoptoticproteinsorproapoptoticBAK.ItinducescelldeathinaBAX-dependentfashion.ItcanalsoinducethebiochemicalandmorphologicfeaturesofBAX-mediatedapoptosisinBak-/-MEFs.BAM7isselectivefortheBH3-bindinggrooveattheN-terminalfaceofBAXandthusmayserveasapowerfulchemicaltoolfordissectingthephysiologicconsequencesofdirectBAXactivationinavarietyofhomeostaticandpathologicconditions.
HowtoUse:
Invitro:BAM7wasusedat10-30µMfinalconcentrationinvitroandincellularassays.
Invivo:n/a
Reference:
- 1.GavathiotisE,etal.Directandselectivesmall-moleculeactivationofproapoptoticBAX.(2012)NatChemBiol.8(7):639-45.
BAM7_spec.pdf
BAM7_MSDS.pdf
Productsareforresearchuseonly.Notforhumanuse.
Xcess生物科学公司(XcessBio)成立于2008年,由一群顶尖的科学家来自学术界和制药/生物技术产业具有较强的专业知识在药物化学、生物化学、分子和细胞生物学。
