Xcessbio/环孢菌素A、MPTP抑制剂和HSC保护剂Xcessbio Biosciences Inc/2 mg固体/M60262-2s

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¥780.00
货号:M60262-2s
浏览量:127
品牌:Xcess
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MolecularWeight:1202.63
Formula:C62H111N11O12
Purity:≥98%
CAS#:59865-13-3
Solubility:DMSOupto100mM,EtOHupto50mM
Storage:Powder:4oC1year.DMSO:4oC3month;-20oC1year.

BIOLOGicalActivity:CyclosporinAisaninhibitorofthemitochondrialpermeABIlitytransitionpore(MPTP).ItprotectsmousebonemarrowandhumancordbloodHSCsfromEPHOSSduringcollectioninair,resultinginincreasedrecoveryoftransplantableHSCs.Itwasusedasimmunosuppressantandcouldinhibitphosphataseactivityofcalcineurin(IC50~5nM).HowtoUse:Invitro:CyclosporinAwasusedat50µg/mlinthecollectionofcordbloodprocess.Invivo:n/aReference:

  • 1.MantelCR,etal.EnhancingHematopoieticStemCellTransplantationEfficacybyMitigatingOxygenShock.(2015)Cell.161(7):1553-65.
  • 2.YanP,etal.Cyclosporin-ApotentlyinduceshighlycardiogenicProgenitorsfromembryonicstemcells.(2009)BiochemBiophysResCommun.379(1):115-20.
  • 3.FrumanDA,etal.CalcineurinphosphataseactivityinTlymphocytesisinhibitedbyFK506andcyclosporinA.(1992)ProcNatlAcadSciUSA.89(9):3686-90.
Cyclosporin_A_spec.pdf
Cyclosporin_A_MSDS.pdfProductsareforresearchuseonly.Notforhumanuse.

Xcess生物科学公司(XcessBio)成立于2008年,由一群顶尖的科学家来自学术界和制药/生物技术产业具有较强的专业知识在药物化学、生物化学、分子和细胞生物学。