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蚂蚁淘在线 / 品牌中心 / Xcess / Xcessbio/BMI1小鼠单克隆抗体Xcessbio Biosciences Inc/Bulk Request/A90010-b

Xcessbio/BMI1小鼠单克隆抗体Xcessbio Biosciences Inc/Bulk Request/A90010-b

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货号：A90010-b
浏览量：127
品牌：Xcess
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Clonality:MonoclonalSource:Mouse
Detectedband(bywestern)MW:37KDCross-Reactivity:Human
Concentration:100ug/100ul
Applications:ELISA1/10000,WB1/500-1/2000,IHC1/200-1/1000,ICC1/200-1/1000,FCM1/200-1/400

Alt.Names

H3histoneantibody,HIST1H3Aantibody,Histonecluster1,H3aantibody

Specificity:

BMI1antibodydetectsendogenouslevelsoftotalBMI1

Immunogen:

PurifiedrecombinantfragmentofhumanBMI1expressedinE.Coli

Purification:

Affinity-chromatography

StorageConditionandBuffer:

MouseIgG1inphosphatebufferedsaline(withoutMg2+andCa2+),pH7.4,150mMNaCl,0.02%sodiumazideand50%glycerol.Storeat-20°C.Stablefor12monthsfromdateofreceipt.

Background:

PolycombcomplexproteinBMI-1isfoundacanonicalself-renewalregulator.TumorFormationand,morespecifically,humancolorectalcancer-initiatingcells(CIC)aredependentonBMI-1.Down-regulationofBMI-1inhibitstheABIlityofcolorectalCICstoself-renew,resultingintheabrogationoftheirtumOrigenicpotential.TargetingtheBMI-1self-renewalmachineryrepresentsapromisingapproachtotheeliminationofmanycancerstem(andinitiating)cells.

BIMI-1antibodydetectsendogenouslevelsoftotalBMI-1,thusagoodtoolofBMI-1relatedcancerstudy.

PleasereferPDFfileforWestern,Immunofluorescenceanalysis,ChromatinimmunoprecipitationanalysisorotherQCdata.

PDF:

BMI1_monocolonal_Antibody

SDS:

SDS_BMI1_mouse_monoclonal_antibody_.pdf

Reference:

  1. KresoA,etal.Self-renewalasatherapeutictargetinhumancolorectalcancer.(2014)NatMed.(1):29-36.

Productisforresearchuseonly.Notforhumanuse.

Xcess生物科学公司(XcessBio)成立于2008年,由一群顶尖的科学家来自学术界和制药/生物技术产业具有较强的专业知识在药物化学、生物化学、分子和细胞生物学。