快报
欢迎光临蚂蚁淘在线！ 请登录 免费注册
商品
品牌
文章
热门搜索：
快报
品牌首页 品牌新闻 品牌简介 产品中心 品牌咨询 联系我们
品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
蚂蚁淘在线 / 品牌中心 / Xcess / Xcessbio/RG108---DNA甲基转移酶抑制剂Xcessbio Biosciences Inc/2 mg固体/M60176-2s

Xcessbio/RG108---DNA甲基转移酶抑制剂Xcessbio Biosciences Inc/2 mg固体/M60176-2s

价格
￥1300.00
货号：M60176-2s
浏览量：105
品牌：Xcess
服务
全国联保
正品保证
正规发票
签订合同
商品描述
Details
ProductInformation
MolecularWeight:334.33
Formula:C19H14N2O4
Purity:≥98%
CAS#:48208-26-0
Solubility:DMSOupto100mM
ChemicalName:(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoicacid
Storage:Powder:4oC1year.DMSO:4oC3month;-20oC1year.

BIOLOGicalActivity:

RG108isapotent,selectiveandcellpermeableinhibitorofDNAmethyltransferase.Unlike5-azaC,RG108isnotanucleosideandthereforedoesnotmodifyDNA.ItbindstotheenzymeactivesiteandinhibitsDNMTenzymaticactivitywithanIC50~115nM.ItinhibitsDNAmethylationinhumancancercelllinesinvitrowithoutdetectabletoxicity.TreatmentwithRG108resultsinthedemethylationofgenomicDNAandcanreactivateepigeneticallysilencedtumorsuppressorgenes.Ithasbeenshowntoimprovethereprogrammingefficiencyofmouseembryonicfibroblasts(MEFs)intoinducedpluripotentstem(iPS)cells.RG108canpotentiallybeusedtomaintainembryonicstem(ES)cellsinanundifferentiatedstateaswellasreplacetranscriptionfactorsinbothmouseandhumancellreprogramming.

HowtoUse:

  • Invitro:RG108wasusedat10-100µMfinalconcentrationinvariousinvitroassays.
  • Invivo:n/a

Reference:

  1. 1.BruecknerB,etal.Epigeneticreactivationoftumorsuppressorgenesbyanovelsmall-moleculeinhibitorofhumanDNAmethyltransferases.(2005)CancerRes.65(14):6305-11.
  2. 2.StresemannC,etal.FunctionaldiversityofDNAmethyltransferaseinhibitorsinhumancancercelllines.(2006)CancerRes.66(5):2794-800.
  3. 3.SchirrmacherE,etal.SynthesisandinvitroevaluationofbiotinylatedRG108:ahighaffinitycompoundforstudyingbindinginteractionswithhumanDNAmethyltransferases.(2006)BioconjugChem.17(2):261-6.
  4. 4.ShiY,etal.InductionofpluripotentstemcellsfrommouseembryonicfibroblastsbyOct4andKlf4withsmall-moleculecompounds.(2008)CellStemCell.3(5):568-74.
  5. 5.PashaZ,etal.Efficientnon-viralreprogrammingofmyoblaststostemnesswithasinglesmallmoleculetogeneratecardiacProgenitorcells.(2011)PLoSOne.6(8):e23667.

  • RG108_spec.pdf
  • RG108_MSDS.pdf

Productsareforresearchuseonly.Notforhumanuse.

Xcess生物科学公司(XcessBio)成立于2008年,由一群顶尖的科学家来自学术界和制药/生物技术产业具有较强的专业知识在药物化学、生物化学、分子和细胞生物学。