Xcessbio/iN LSC Xcessbio Biosciences Inc/1000X;0.5 ml/S10004

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¥1780.00
货号:S10004
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品牌:Xcess
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ProductInformation
Purity:≥98%foreachcompound
Storage:4oCfor3month.-20oCfor6month.
CocktailFormulation:0.5mMLDN193189,10mMSB431542,2mMCHIR99021inDMSOsolution

BIOLOGicalActivity:

Inpreviousstudies,dualSMADinhibitionusingsmallmoleculeinhibitorsofBMPandTGFβpathways,i.e.,LDN193189andSB431542respectively,hasbeenshowntoinduceefficientneuraldifferentiationofhumanpluripotentstemcells.Inarecentpublication,itwasshownthatcombinationofLDN193189/SB431542withaspecificGSK-3βinhibitor(CHIR99021)couldsignificantlypromotetheconversionofpostnatalhumanfibroblaststransducedwithAscl1andNgn2intofunctionalneuron-likecellswithyieldsupto200%andneuronalpuritiesupto80%.

HowtoUse:

  • Invitro:DilutereceivedReady-to-useiN-LSCstocksolutionat1:1000intoyourneuronalreprogramingmediumtomaketheneuroninductionmediaanduseittoinitiateneuronalreprogramming.

Reference:

  1. 1.LadewigJ,etal.Smallmoleculesenablehighlyefficientneuronalconversionofhumanfibroblasts.(2012)NatureMethods9(6),p575-578.
  • ProductSpecification:
  • Kit-iN-LSC_spec.pdf
  • ProductMSDS:
  • Kit-iN-LSC_MSDS.pdf

Productsareforresearchuseonly.Notforhumanuse.

Xcess生物科学公司(XcessBio)成立于2008年,由一群顶尖的科学家来自学术界和制药/生物技术产业具有较强的专业知识在药物化学、生物化学、分子和细胞生物学。