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蚂蚁淘在线 / 品牌中心 / Xcess / Xcessbio/Nocodazole, Microtubule Inhibitor / CRISPR Editing Enhancer-Xcessbio Biosciences Inc/2 mg solid/M60331-2s

Xcessbio/Nocodazole, Microtubule Inhibitor / CRISPR Editing Enhancer-Xcessbio Biosciences Inc/2 mg solid/M60331-2s

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￥1580.00
货号：M60331-2s
浏览量：127
品牌：Xcess
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MolecularWeight:301.32
Formula:C14H11N3O3S
Purity:≥98%
CAS#:31430-18-9
Solubility:DMSOupto50mM
ChemicalName:methyl(5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-yl)carbamate
Storage:Powder:4oC1year.DMSO:4oC3month;-20oC1year.

BIOLOGicalActivity:Nocodazoleisapotentmicrotubuleinhibitortoinhibitmitosis.Itdisruptsmicrotubulesbybindingtoβ−tubulinandpreventingformationofoneofthetwointerchaindisulfidelinkages,thusinhibitingmicrotubuledynamics,disruptionofmitoticspindlefunction,andfragmentationoftheGolgicomplex.NocodazolearreststhecellcycleatG2/MphaseandalsopreventsphosphorylationoftheTcellantigenreceptorandinhibitsitsactivity.NocodazolestimulatestheintrinsicGTPaseactivityoftubulinandactivatestheJNK/SAPKsignalingpathwayandinducesapoptosisinseveralnormalandtumorcelllines.Nocodazoleenhanceshomology-directedrepair(HDR)efficiency9to31%(dependingoncellcyclephase)andincreasesCas9-mediatedgeneeditingfrequencies.HowtoUse:Invitro:Nocodazolewasusedat200ng/mlinvitroandcellularassays.Invivo:n/aReference:

  • 1.VasquezRJ,etal.NanomolarconcentrationsofnocodazolealtermicrotubuledynamicinstABIlityinvivoandinvitro.(1997)MolBiolCell.8(6):973-85.
  • 2.WebbJL,etal.Microtubuledisruptioninhibitsautophagosome-lysosomefusion:implicationsforstudyingtherolesofaggresomesinpolyglutaminediseases.(2004)IntJBiochemCellBiol.36(12):2541-50.
  • 3.MizushimaN,etal.Methodsinmammalianautophagyresearch.(2010)Cell.140(3):313-26.
  • 4.LinS,etal.Enhancedhomology-directedhumangenomeengineeringbycontrolledtimingofCRISPR/Cas9delivery.(2014)Elife.3:e04766.
nocodazole_spec.pdf
Nocodazole_MSDS.pdf
Productsareforresearchuseonly.Notforhumanuse.

Xcess生物科学公司(XcessBio)成立于2008年,由一群顶尖的科学家来自学术界和制药/生物技术产业具有较强的专业知识在药物化学、生物化学、分子和细胞生物学。