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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Details
L755507_spec.pdfL755507_MSDS.pdf
ProductInformation
| MolecularWeight: | 584.73 |
| Formula: | C30H40N4O6S |
| Purity: | ≥98% |
| CAS#: | 159182-43-1 |
| Solubility: | DMSOupto100mM |
| ChemicalName: | (S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide |
| Storage: | Powder:4oC1year.DMSO:4oC3month;-20oC1year. |
BIOLOGicalActivity:
L-755,507waspreviouslycharacterizedasapotentandselectiveβ3adrenergicreceptorpartialagoNISTwithEC50~0.43nM.Ithas>1000foldselectivityoverβ1-andβ2-adrenoceptors(EC50~580nMand>10000nMforβ1-andβ2-adrenoceptorsrespectively).ItstimulateslipolysisinrhesusADIpocytesinvitro(EC50=3.9nM).Inarecentstudy,L-755,507wasidentifiedtoenhanceCRISPR-mediatedhomology-directedrepair(HDR)efficiencyinhumaninducedpluripotentstemcells(iPSCs)andothercelltypes.
HowtoUse:
Invitro:L-755,507wasusedat1-5µMfinalconcentrationinvariousinvitroassays.
Invivo:L-755,507stimulatesmetabolicrateby30%afteracutebolusintravenousadministrationof0.1mg/kgtorhesusmonkeys.
Reference:
- 1.FisherMH,etal.Aselectivehumanbeta3adrenergicreceptoragonistincreasesmetabolicrateinrhesusmonkeys.(1998)JClinInvest.101(11):2387-93.
- 2.ParmeeER,etal.DiscoveryofL-755,507:asubnanomolarhumanbeta3adrenergicreceptoragonist.(1998)BioorgMedChemLett.8(9):1107-12.
- 3.YuC,etal.SmallMoleculesEnhanceCRISPRGenomeEditinginPluripotentStemCells.(2015)CellStemCell16(2):142-7.
L755507_spec.pdfL755507_MSDS.pdfProductsareforresearchuseonly.Notforhumanuse.