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蚂蚁淘在线 / 品牌中心 / Sciencell / Sciencell/重组鼠NOGGIN/128-09/1 Ea

Sciencell/重组鼠NOGGIN/128-09/1 Ea

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￥1460.00
货号：128-09
浏览量：127
品牌：Sciencell
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商品描述
Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
NogginbelongstoagroupofdiffusIBLeproteinswhichbindtoligandsoftheTGF-αfamilyandregulatetheiractivitybyinhibitingtheiraccesstosignalingreceptors.TheinterplaybetweenTGF-αligandsandtheirnaturalantagoNISTshasmajorBIOLOGicalsignificanceduringdevelopmentprocesses,inwhichcellularresponsecanvaryconsiderablydependinguponthelocalconcentrationofthesignalingmolecule.NogginwasoriginallyidentifiedasaBMP-4antagonistwhoseactioniscriticalforproperformationoftheheadandotherdorsalstructures.Consequently,NogginhasbeenshowntomodulatetheactivitiesofotherBMPsincludingBMP-2,-7,-13,and-14.TargeteddeletionofNoggininmiceresultsinprenataldeathandrecessivephenotypedisplayingaseverelymalformedskeletalsystem.Conversely,transgenicmiceover-expressingNoggininmatureosteoblastsdisplayimpairedosteoblasticdifferentiation,reducedboneformation,andsevereosteoporosis.TheaminoacidsequenceofhumannogginishighlyhomologoustothatofXenopus,ratandmouse.

Specifications:

CatalogNo.128-09
CountryofManufactureUnitedStates
ProductCodermNOGGIN
Size/Quantity5μg
ProductUseThisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
StorageStoreat-20°Cafterreceiving.UponReconstitution,storeat2-8°Cforuptooneweek.FormaximalstABIlity,aliquotandstoreat-20°C.Avoidrepeatedfreeze/thawcycles.
ShippingInfoDryice
SynonymsRP23-205A9.1
AASequenceMQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGPAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC
SourceEscherichiacoli
MolecularWeightApproximately46.4kDadisulfide-linkedhomodimerconsistingoftwo206aminoacidpolypeptidechains.
Purity>95%bySDS-PAGEandHPLCanalyses.
BiologicalActivityFullybiologicallyactive.TheED50is1-2ng/ml,asdeterminedbyitsabilitytoinhibit5ng/mlofBMP4-inducedalkalinephosphataseproductioninATDC-5chondrogeniccells.
PhysicalAppearanceWhitelyophilizedpowder.
FormulationLyophilizedfroma0.2μmfilteredconcentratedsolutionin30%acetonitrile,0.1%TFA.
Endotoxin
ReconstitutionReconstitutein10mMHActoaconcentrationof0.1-1.0mg/mL.
SciencCell公司 是1999年成立于美国洛杉矶圣地亚哥，是一家快速成长的生物技术公司，其一直专注于是研发实验和治疗相关的细胞产品。ScienCell公司提供多种多样、高质量的人和动物的原代细胞，原代细胞培养基、干细胞研究相关领域产品和相关试剂。