The eye contains highly vascularised and completely avascular tissues in close apposition. This specialized anatomy requires tight regulation of the balance between vascular quiescence and vascular growth. Retinal vascularization is a coordinated interaction of vascular cells, including endothelial cells, pericytes, and astrocytes, and a balanced production of positive and negative regulatory factors [1]. In eye diseases associated with angiogenesis, this delicate balance is disturbed. Angiogenesis plays a crucial role in disorders responsible for most blindness such as diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, as well as a large number of other eye conditions. Studies of retinal capillary endothelial cells have shed light on the earliest stages of diabetic retinopathy and other diseases of the retinal microvasculature [2, 3]. Human retinal endothelial cell cultures will surely continue to provide an in vitro model in the pathophysiological studies of vascular diseases in the human eye.

有没有用这个细胞HREC 6530发表的文章，影响因子稍微好一点的