Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
Tumornecrosisfactoralpha(TNF-α)isproducedbyneutrophils,activatedlymphocytes,macrophages,NKcells,LAKcells,astrocytesendothelialcells,smoothmusclecellsandsometransformedcells.TNF-αoccursasasecreted,solubleformandasamembrane-anchoredform,bothofwhichareBIOLOGicallyactive.Thenaturally-occurringformofTNF-αisglycosylated,butnon-glycosylatedrecombinantTNF-αhascomparable.ThebiologicallyactivenativeformofTNF-αisreportedlyatrimer.HumanandmurineTNF-αshowapproximately79%homologyattheaminoacidlevelandcrossreactivitybetweenthetwospecies.

Specifications:

CatalogNo.	123-01
CountryofManufacture	UnitedStates
ProductCode	rmTNF-α
Size/Quantity	5μg
ProductUse	Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
Storage	Storeat-20°Cafterreceiving.UponReconstitution,storeat2-8°Cforuptooneweek.FormaximalstABIlity,aliquotandstoreat-20°C.Avoidrepeatedfreeze/thawcycles.
ShippingInfo	Dryice
Synonyms	Cachectin,DIF,TNFA,TNFa,TNFSF2,TNF-alpha,APC1protein
AASequence	MLRSSSQNSSDKPVAHVVANHQVEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQGCPDYVLLTHTVSRFAISYQEKVNLLSAVKSPCPKDTPEGAELKPWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAESGQVYFGVIAL
Source	Escherichiacoli
MolecularWeight	Approximately17.3kDa,asoluble157aminoacidproteinwhichcorrespondstoC-terminalextracellulardomainofthefulllengthtransmembraneprotein.
Purity	>95%bySDS-PAGEandHPLCanalyses.
BiologicalActivity	Fullybiologicallyactive.ED50is1
PhysicalAppearance	Whitelyophilizedpowder.
Formulation	Lyophilizedfroma0.2μmfilteredconcentrated(1mg/ml)solutioninPBS,pH7.2.
Endotoxin
Reconstitution	Reconstituteinsteriledistilledwatercontaining0.1%BSAtoaconcentrationof0.1-1.0mg/mL.

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