Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
BMPs(BoneMorphogeneticProteins)belongtotheTGF-betaofsignalingproteinsandwereoriginallyidentifiedasproteinregulatorsofcartilageandboneformation.However,theyhavesincebeenshowntobeinvolvedinembryogenesisandmorphogenesisofvarioustissuesandorgans.BMPshavealsobeenshowntoregulatethegrowth,differentiation,chemotaxisandapoptosisofvariouscelltypes,includingmesenchymalcells,epithelialcells,hematopoieticcellsandneuronalcells.ReductioninBMP-4expressionisassociatedwithanumberofbone-relateddiseases,includingFibrodysplasiaOssificansProgressiva.BMP-4issynthesizedaslargeprecursormoleculewhicharecleavedbyproteolyticenzymes.Theactiveformcanbefoundashomodimersorheterodimers.

Specifications:

CatalogNo.	108-04
CountryofManufacture	UnitedStates
ProductCode	rhBMP-4
Size/Quantity	2μg
ProductUse	Thisproductisforresearchuseonly.Itisnotapprovedforuseinhumans,animals,orinvitrodiagnosticprocedures.
Storage	Storeat-20°Cafterreceiving.UponReconstitution,storeat2-8°Cforuptooneweek.FormaximalstABIlity,aliquotandstoreat-20°C.Avoidrepeatedfreeze/thawcycles.
ShippingInfo	Dryice
Synonyms	BMP4,ZYME,BMP2B,OFC11,BMP2B1,MCOPS6
AASequence	SPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Source	Escherichiacoli
MolecularWeight	Approximately13kDa,amonomeric,non-glycosylatedpolypeptidechaincontaining116aminoacids.
Purity	>95%bySDS-PAGEandHPLCanalyses.
BIOLOGicalActivity	Fullybiologicallyactive.
PhysicalAppearance	Whitelyophilizedpowder.
Formulation	Lyophilizedfroma0.2μmfilteredconcentrated(1mg/ml)solutionin20mMNa2CO3buffer,pH9.0.
Endotoxin
Reconstitution	Reconstituteinsteriledistilledwatercontaining0.1%BSAtoaconcentrationof0.1-1.0mg/mL.

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