MSMafromScienCellResearchLaboratoriesareisolatedfromadultCD-1mousespleen.MSMaarecryopreservedafterpurificationanddeliveredfrozen.Eachvialcontains>1x10^6cellsin1mlvolume.

Macrophagesarecellsdifferentiatedfromcirculatingbonemarrow-derivedmonocytes.ThemainfunctionofmacrophagesistoremovecellulardebrisanddestroyinvADIngpathogens.MouseSplenicMacrophages(MSMa)resideinthespleenandplayacriticalroleinmaintainingbloodhomeostasis[1].Therearethreedistinctpopulationsofsplenicmacrophagesincluding:redpulpmacrophages,marginalzonemacrophages,andmarginalzonemetallophillicmacrophages[1,2].MSMaperformironprocessingfunctionsandaidinthecaptureofmicrobesandvirusesinthecirculatorysystem[1,2].Recentstudieshaveshownthatsplenicmacrophagescontributetostrokepathologyandautoimmunediseases[3,4].MSMaareanexcellentmodelforstudyingmacrophagefunctionsundernormalphysiologicalandpathologicalconditions.

MSMafromSciencellResearchLaboratoriesareisolatedfromadultCD-1mousespleen.MSMaarecryopreservedafterpurificationanddeliveredfrozen.Eachvialcontains>1x10^6cellsin1mlvolume.MSMaarecharacterizedbyimmunofluorescencewithantibodytoF4/80.MSMaarenegativeformycoplasma,bacteria,yeast,andfungi.MSMaareguaranteedtofurthercultureintheconditionsprovidedbyScienCellResearchLaboratories;however,MSMaarenotrecommendedforexpandingorlong-termculturessincethecellsdonotproliferateinregularculture. 

Specifications:

CatalogNo.	M5550
CountryofManufacture	UnitedStates
ProductCode	MSMa
Size/Quantity	Eachvialcontains>1x10^6cellsin1mlvolume
ProductUse	MSMaareforresearchuseonly.Theyarenotapprovedforhumanoranimaluse,orforapplicationininvitrodiagnosticprocedures.
Storage	Uponreceiving,directlyandimmediatelytransferthecellsfromdryicetoliquidnitrogenandkeepthecellsinliquidnitrogenuntiltheyareneededforexperiments.
ShippingInfo	Dryice.
References	[1]BorgesdaSilvaH,FonsecaR,PereiraR,CassadoAdosA,AlvarezJ,D"Imperio,LimaM.(2015)"Splenicmacrophagesubsetsandtheirfunctionduringblood-borneinfections."FrontImmunol.6:480.[2]GammellaE,BurattiP,CairoG,RecalcatiS.(2014)"Macrophages:centralregulatorsofironbalance."Metallomics.6(8):1336-1345.[3]LiuZ,ChenCLiF,ShenJ,YangY,LeakR,JiX,DuH,HuX.(2015)"Splenicresponsesinischemicstroke:newinsightsintostrokepathology."CNSNeurosciTher.21(4):320-326.[4]McGabaT,KarlssonM.(2016)"Apoptoticcellresponsesinthesplenicmarginalzone:aparadigmforimmunologicreactionstoapoptoticantigenswithimplicationsforautoimmunity."ImmunolRev.269(1):26-43.

SciencCell公司 是1999年成立于美国洛杉矶圣地亚哥，是一家快速成长的生物技术公司，其一直专注于是研发实验和治疗相关的细胞产品。ScienCell公司提供多种多样、高质量的人和动物的原代细胞，原代细胞培养基、干细胞研究相关领域产品和相关试剂。