Description:

Isotype: Rabbit IgG Positive Control: Placenta

Staining Pattern: Cytoplasmic

Immunogen: A synthetic peptide from the catalytic domain of mouse MMP-15 / MT2-MMP protein. MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.

Additional Information:

Name	MMP-15/MT2-MMP, Antibody
Related Product Names	MMP-15 EPITOPE SPECIFIC RABBIT ANTIBODY MMP-15/MT2-MMP
Source	Rabbit
Applications	IHC-P, WB
Clonality	Polyclonal
Format	1.0 ml affinity purified rabbit polyclonal antibody at 0.2mg/ ml in 10mM PBS, pH 7.4 with BSA and Sodium Azide.
Reactivity	Human, mouse
Storage	Ab with sodium azide is stable for 24 months when stored at 2-8C.
Intended Use	Research Use Only

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