- Practical synthesis of C1 deut...
- Regulation of Spermatogenesis ...
- 美国LACTEL生物医用降解聚合物有超过30年生产高品质降解...
- 商务部:调整美国及部分欧盟公司进口乙二醇和二甘醇反倾销税 ....
- 心肌酶谱检查结果怎么看 妈妈网百科
- 华夏源SNC细胞集团
- I型胶原蛋白(CollagenI)ELISA试剂盒说明书和原...
- 神经电生理监测的临床应用
- 细胞生物学:PCR简介及污染的处理
- 新研究有助理解细胞中基因表达调控的分子机制_手机网易网
- Cell:令人意外!细菌DNA遭受压缩时仍保持它的基因表达_...
- 【求助】纯化重组蛋白多克隆抗体的方法 免疫学讨论版论坛
- [01-23]全国高考生物真题汇编遗传的物质基础(DNA的结构、复制、转录、...
- [03-02]简述基因的转录过程_简述基因表达过程中复制和转录的区别_完美...
- [01-24]...A.基因表达包括转录和翻译两个过程.均发生在细胞核中B.转录...
- [01-21]肝癌及癌旁肝组织的高尔基体差异蛋白质分析
- [07-21]基因转录_标签_网易财经
- [07-20]【求助】请教大家一个关于报告基因质粒瞬时转染与报告基因表达的...
- [07-24]研究揭示植物中存在单等位基因表达
- [07-26]基因表达的转录过程
- [02-27]复制与转录的关系复制与转录是同时进行的吗?还是DNA复制完再进...
RegulationofPGC1a
Peroxisomeproliferator-activatedreceptorgammacoactivator-1alpha(PGC-1a)isatissue-specificcoactivatorthatenhancestheactivityofmanynuclearreceptorsandcoordinatestranscriptionalprogramsimportantforenergymetabolismandenergyhomeostasis.InappropriateincreasesinPGC-1aactivityhavebeenlinkedtoanumberofpathologicalconditionsincludingheartfailureanddiabetes.PGC-1aishighlyexpressedinmetabolicallyactivetissuesincludingbrownfat,skeletalmuscleandheart.PGC-1ahasbeenimplicatedinmitochondrialbiogenesisintheheartandincreasedmitochondrialrespirationinbrownfat.PGC-1aisacoactivatorformanyfactorsincluding,CBP,Scr-1,PPARa,GR(glucocorticoidreceptor),THR(thyroidhormonereceptor),severalorphanreceptorsandMEF2.ThispathwayillustratestwoofthecofactorregulatoryfactorsMEF2andPPARa)andanexampleorphanreceptorfeedbackinhibitionloop.Glut4isusedasanexampleofthedownstreamelementsleADIngtochangesinmetabolism.IchidaetaldiscoveredtheERRarepressionofPGC-1a.TheirresultssuggestanovelmechanismoftranscriptionalcontrolwhereinERR-acanfunctionasaspecificmolecularrepressorofPGC-1a.Thissuggeststhatotherco-activatorsmightalsohavespecificrepressors,addinganotherlayerofcombinatorialcomplexityintranscriptionalregulation.CzubrytetalidentifiedPGC-1aasakeytargetoftheMEF2/HDACregulatorypathwayanddemonstratedthispathway"simportanceinmaintenanceofcardiacmitochondrialfunction.ThelinkingofMEF2/HDACprovidesanpotentialexplanationfortheincreaseinmitochondrialnumberobservedinresponsetoCaMKsignaling.
Contributor:
REFERENCES:BergerI,BieniossekC,SchaffitzelC,HasslerM,SantelliE,RichmondTJ.DirectinteractionofCa2+/calmodulininhibitshistonedeacetylase5repressorcorebindingtomyocyteenhancerfactor2.JBiolChem.2003Mar6[epubaheadofprint]CzubrytMP,McAnallyJ,FishmanGI,OlsonEN.Regulationofperoxisomeproliferator-activatedreceptorgammacoactivator1alpha(PGC-1alpha)andmitochondrialfunctionbyMEF2andHDAC5.ProcNatlAcadSciUSA.2003Feb18;100(4):1711-6.IchidaM,NemotoS,FinkelT.Identificationofaspecificmolecularrepressoroftheperoxisomeproliferator-activatedreceptorgammaCoactivator-1alpha(PGC-1alpha).JBiolChem.2002Dec27;277(52):50991-5.KresslerD,SchreiberSN,KnuttiD,KralliA.ThePGC-1-relatedproteinPERCisaselectivecoactivatorofestrogenreceptoralpha.JBiolChem.2002Apr19;277(16):13918-25.MeredithL.Moore,EdwardsA.ParkandJeanieB.McMillin,Upstreamstimulatoryfactorrepressestheinductionofcarnitinepalmitoyltransferase-IbetaexpressionbyPGC-1.JBiolChem.2003Feb28[epubaheadofprint]SchreiberSN,KnuttiD,BrogliK,UhlmannT,KralliA.TheTranscriptionalCoactivatorPGC-1RegulatestheExpressionandActivityoftheOrphanNuclearReceptorEstrogen-RelatedReceptoralpha(ERRalpha).JBiolChem.2003Mar14;278(11):9013-8.
================ 蚂蚁淘在线 ================
免责声明:本文仅代表作者个人观点,与本网无关。其创作性以及文中陈述文字和内容未经本站证实,对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺,请读者仅作参考,并请自行核实相关内容
版权声明:未经蚂蚁淘在线授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的,应该授权范围内使用,并注明“来源:蚂蚁淘在线”。违反上述声明者,本网将追究其相关法律责任。