- 人可溶性髓系细胞触发受体1(sTREM1)ELISA试剂盒货...
- 新版纯水标准《仪器分析用高纯水规格及试验方法》的解读_食品机...
- 做血清、血浆、细胞的Elisa试剂盒可以测组织匀浆么?
- 密胺树脂_化工百科
- 英特尔 SoC FPGA 开发者论坛 (ISDF)预约报名享...
- 【什么是腐蚀测试中的NSS,AASS和CASS?】技术论文 ...
- 请问投稿后,编辑发来个"preprint&...
- 网上的骰宝_品牌馆_医流商城分销服务和交易平台
- 小鼠单克隆抗体的制备与纯化
- 靶向细胞自噬关键蛋白小分子抑制剂的发现,确证和机制...
- [生理学]类固醇激素不包括:
- 新研究有助理解细胞中基因表达调控的分子机制_手机网易网
- [03-04]讨论可通过增加基因的转录活性 直接诱导 的产生 同时提高 的表达和 ...
- [03-02]简述基因的转录过程_简述基因表达过程中复制和转录的区别_完美...
- [01-23]全国高考生物真题汇编遗传的物质基础(DNA的结构、复制、转录、...
- [02-25]基因表达的检测的几种方法
- [08-02]聚苯乙烯硫酸分子量标准品品牌:甄准生物进口原装规格:250mg含量99%...
- [01-24]...A.基因表达包括转录和翻译两个过程.均发生在细胞核中B.转录...
- [07-22]转录组和表达谱有什么区别? 有奖问答 学术 科研...
- [07-24]研究揭示植物中存在单等位基因表达
- [03-05]转录组测序和数字表达谱测序区别
美国LACTEL生物医用降解聚合物有超过30年生产高品质降解性聚合物的经验...
Mitogen-activatedprotein(MAP)kinasesareimportantplayersinsignaltransductionpathwaysactivatedbyarangeofstimuliandmediateanumberofphysiologicalandpathologicalchangesincellfunction.TherearethreemajorsubgroupsintheMAPKfamily:ERK,p38,andJNK/SAPK.ERKisactivatedmainlybymitogenicstimuli,whereasp38andJNK/SAPKareactivatedmainlybystressstimuliorinflammatorycytokines.MAPkinasesarepartofathree-tieredphosphorylationcascadeandMAPkinasephosphorylationonathreonineandtyrosineresiduelocatedwithintheactivationloopofkinasesuBDomainVIIIresultsinactivation.However,thisprocessisreversIBLeeveninthecontinuedpresenceofactivatingstimuli,indicatingthatproteinphosphatasesprovideanimportantmechanismforMAPkinasecontrol.Dualspecificityphosphatases(DSP’s)fromtyrosinephosphatase(PTP)genesuperfamilyareselectivefordephosphorylatingthecriticalphosphothreonineandphosphotyrosineresidueswithinMAPkinases.TenmembersofdualspecificityphosphatasesspecificallyactingonMAPKs,termedMAPKphosphatases(MKPs),havebeenreported.TheysharesequencehomologyandarehighlyspecificforMAPK’sbutdifferinthesubstratespecificity,tissuedistribution,subcellularlocalization,andinducibilitybyextracellularstimuli.MKPshavebeenshowntoplayimportantrolesinregulatingthefunctionoftheMAPKfamily.DSPgeneexpressionisinducedstronglybyvariousgrowthfactorsand/orcellularstresses.Expressionofsomegenefamilymembers,includingCL100/MKP-1,hVH-2/MKP-2,andPAC1,isdependentatleastinpartonMAPkinaseactivationprovidingnegativefeedbackfortheinducingMAPkinaseorforregulatorycrosstalkbetweenparallelMAPkinasepathways.DSPsarelocalizedtodifferentsubcellularcompartmentsandcertainfamilymembersappearhighlyselectiveforinactivatingdistinctMAPkinaseisoforms.ThisenzymaticspecificityisduetocatalyticactivationoftheDSPphosphataseaftertightbindingofitsamino-terminaltothetargetMAPkinase.Thus,DSPphosphatasesprovideasophisticatedmechanismfortargetedinactivationofselectedMAPkinaseactivities.
Contributor:A.Konev,PhD
REFERENCES:CampsMetal.Dualspecificityphosphatases:agenefamilyforcontrolofMAPkinasefunction.FASEBJ.2000;14(1):6-16.TheodosiouA,AshworthA.MAPkinasephosphatases.GenomeBiol.2002;26;3(7)
================ 蚂蚁淘在线 ================
免责声明:本文仅代表作者个人观点,与本网无关。其创作性以及文中陈述文字和内容未经本站证实,对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺,请读者仅作参考,并请自行核实相关内容
版权声明:未经蚂蚁淘在线授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的,应该授权范围内使用,并注明“来源:蚂蚁淘在线”。违反上述声明者,本网将追究其相关法律责任。