人巨细胞病毒PP65/CMV低基质磷脂蛋白抗体

编号：XY-0271R

Cytomegalovirusisamemberoftheherpesvirusgroup,whichincludesherpessimplexvirustypes1and2,varicellazostervirus(whichcauseschickenpox),andEpsteinBarrvirus(whichcausesinfectiousmononucleosis).Thesevirusesshareacharacteristicabilitytoremaindormantwithinthebodyoveralongperiod.CMVviralgenesareco-ordinatelyexpressedingroupsatvarioustimesafterinfection.Earlyviralproteinsareexpressedinthenucleusofinfectedcellswithin3to24hoursofinfectionpriortothecommencementofviralDNAreplication.Thisisfollowedbyexpressionoftheearlyintermediategenes,whichencodeenzymesrequiredforviralDNAreplication.After48to72hours,anumberoflateviralantigensmaybedemonstratedinthenucleiandcytoplasmofinfectedcells.pp65isa65kDphosphorylatedglycoproteinandisthemostabundantofthelateantigens.
Function:CounteractsthehostantiviralimmuneresponsebypreventingIRF3toenterthenucleusonceactivatedandphosphorylated.Participatesalsointhetransactivationofviralmajorimediate-earlygenesbyrecruitinghostIFI16totheirpromoters.
Subunit:InteractswithhostNCL/nucleolin.InteractswithhostIFI16.
SubcellularLocation:Viriontegument(Potential).Hostnucleus.Hostcytoplasm.Note=Aspartoftheincomingvirion,pp65istargetedtothenucleusimmediatelyafterinfection.Thenewlysynthesizedpp65isobservedinthenucleusuntilsometimeafter48hourspostinfection.Thereafter,pp65isprobablyexportedandaccumulatesinthecytoplasm.Alsofoundindensebodies.
TissueSpecificity:Viriontegument(Potential).Hostnucleus.Hostcytoplasm.Note=Aspartoftheincomingvirion,pp65istargetedtothenucleusimmediatelyafterinfection.Thenewlysynthesizedpp65isobservedinthenucleusuntilsometimeafter48hourspostinfection.Thereafter,pp65isprobablyexportedandaccumulatesinthecytoplasm.Alsofoundindensebodies.
Post-translationalmodifications:Phosphorylationmayplayaroleinthelocalizationoftheprotein.
Similarity:Belongstotheherpesviridaepp65family.
Databaselinks:UniProtKB/Swiss-Prot:Q6SW59
UniProtKB/Swiss-Prot:P06725
细胞巨化病毒是一种疱疹病毒,易引起先天性畸形，且患者在接受大量输血和免疫抑制力治疗时它是引起并发症的主要生物因子。
巨细胞病毒是一种感染肺、肾、肠和其他器官的条件致病菌。该抗体识别分子量为52、65、72以及86kDa的立即早期非结构抗原。该抗原在感染2小时后即可被检测到。而感染96小时达到峰值，并持续整个CMV周期。
初期感染此病毒的孕妇中近一半会将此病传播给她的胎儿，被传染的胎儿长大后易智力低下，失明或耳聋。