【产品形式】：艾美捷为您提供的HDAC8（人源重组蛋白)(25ug)产品为：10mMTris,pH7.5,containing100mMsodiumchloride,3mMMgCl2,and20%glycerol

【背景资料】：Histonedeacetylases(HDACs)catalyzethedeacetylationofcorehistones,resultingintighteningofnucleosomalintegrity,restrictionoftheaccessoftranscriptionfactors,andsuppressionoftranscription.HDACsalsoplayanimportantroleinmediatingnuclearreceptorfunctionsbyformingco-repressorcomplexeswithnuclearreceptorsintheabsenceofligands.Theyarealsoinvolvedinmediatingothertranscriptionregulatorypathwaysbyassociatingwithtranscriptionfactors,suchasE2F,TFIIE,TFIIF,NF-κB,p300,Stat3,p53,andtheretinoblastoma(Rb)protein.HDAC8isaClassIHDACwhichisrelatedtotheyeastHDACRpd3.Itisprimarilylocalizedtothenucleuswithubiquitousdistributionthroughouthumancelllinesandtissues.Bymodifyingchromatinstructureandothernon-histoneproteins,HDACsplayimportantrolesincontrollingcomplexbiologicalevents,includingcelldevelopment,differentiation,programmedcelldeath,angiogenesis,andinflammation.Consideringthesemajorroles,itisconceivablethatdysregulationofHDACsandsubsequentimbalanceofacetylationanddeacetylationmaybeinvolvedinthepathogenesisofvariousdiseases,includingcancerandinflammatorydiseases.

CaymanChemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域。CaymanChemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体。作为CaymanChemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的CaymanChemical产品以及客户订制化服务。

点击HDAC8（人源重组蛋白)(25ug)查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询CaymanChemical中国区域授权总代理艾美捷科技有限公司。