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DNA亚硫酸氢盐处理试剂盒.pdf

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TheRM4-5antibodyreactswithmouseCD4,a55kDaproteinwhichactsasaco-receptorfortheTcellreceptor(TCR)initsinteractionwithMHCClassIImoleculesonantigen-presentingcells.TheextracellulardomainofCD4bindstothebeta2-domainofMHCClassII,whileitscytoplasmictailprovidesabindingsiteforthetyrosinekinaselck,facilitatingthesignalingcascadethatinitiatesTcellactivation.CD4istypicallyexpressedonthymocytes,certainmatureTcellpopulationssuchasTh17andTregulatory(Treg)cells,aswellasondendriticcells.

TheRM4-5antibodyiswidelyusedasaphenotypicMarkerforCD4expression.Ifusedtogether,theRM4-5antibodyandanalternativeantibody,Anti-MouseCD4cloneGK1.5,will"compete"forbinding,i.e.RM4-5antibodyisabletoblockGK1.5antibodybindingtocells.Incontrast,RM4-5antibodydoesnotblockthebindingofAnti-MouseCD4cloneRM4-4tocells.

Name	PerCPAnti-MouseCD4(RM4-5)
Cat.No.	67-0042
AlternativeNames	L3T4,T4
GeneID	12504
Clone	RM4-5
Isotype	RatIgG2a,kappa
Reactivity	Mouse
CrossReactivity	No
Format	PerCP
Applications	FlowCytometry
Citations*	WillingerTandFlavellRA.2012.Proc.Natl.Acad.Sci.109:8670-8675.(Flowcytometry) StephenTL,WilsonBS,andLauferTM.2012.Proc.Natl.Acad.Sci.109:7415-7420.(Immunofluorescencemicroscopy) Poitrasson-RiviereM,BienvenuB,LeCampionA,BecourtC,MartinB,andLucasB.2008.J.Immunol.180:7294-7304.(Immunohistochemistry–paraffinembeddedtissue) SorgH,LorchB,JasterR,FitznerB,IbrahimS,HolzhueterS,NizzeH,andVollmarB.2008.Am.J.Physio.Gastrointest.LiverPhysiol.295:G1274-1280.(Immunohistochemistry-paraffinembeddedtissue) MenkeJ,LucasJA,ZellerGC,KeirME,HuangXR,TsuboiN,MayadasTN,LanHY,SharpeAH,andKelleyVR.2007.J.Immunol.179:7466-7477.(Immunohistochemistry–frozentissue) IrieJ,WuY,WickerLS,RainbowD,NalesnikMA,HirschR,PetersonLB,LeungPS,ChengC,MackayIR,GershwinME,andRidgwayWM.2006.JExpMed.203(5):1209-19.(Immunohistochemistry–frozentissue) BosselutR,ZhangW,AsheJM,KopaczJL,SamelsonLE,andSingerA.1999.J.Exp.Med.190:1517-1526.(Immunoprecipitation) ShiY,KaliyaperumalA,LuL,SouthwoodS,SetteA,MichaelsMA,andDattaSK.1998.J.Exp.Med.187:367-378.(Blocking) WhitelandJL,NichollsSM,ShimeldC,EastyDL,WilliamsNA,andHillTJ.1995.J.Histochem.Cytochem.43:313-320.(Immunohistochemistry–frozentissue,zinc-fixedparaffinembeddedtissue)

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