TC-PTP (N term) Mouse Monoclonal Antibody

Mouse

Monoclonal

Signal Transduction, Cell Biology, Immunology, Cancer

N-terminal fragment of TC-PTP

3.00E+02

View Datasheet (PDF)

IgG1

None

mouse, rat, human and monkey

The antibody recognizes the N-terminal portion of TC-PTP; when used for Western blots the antibody detects one band in MEF cells extract, and 2 bands in spleen extract. The antibody recognizes 4 bands of TC-PTP from monkey

Tissue culture supernatant

100 µg

The protein tyrosine phosphatase (PTP) belongs to a large family of enzymes involved in the regulation of cellular signaling and homeostasis, each possessing a 240 amino acid PTP domain. The T-cell protein tyrosine phosphatase (TC-PTP) is predominantly expressed in the hematopoietic lineage. TC-PTP null mice suffer severe defects in the hematopoietic compartment and die at 3-5 weeks of age from severe anemia. TC-PTP -/- murine embryonic fibroblasts have a slow progression through the G1 phase of the cell cycle and have compromised NF-κB activation. JAK 1 and 3 have been identified as physiological substrates of TC-PTP. Recent genetic studies have revealed an association between the PTPN2 (TC-PTP) gene and diseases like type 1 diabetes and Crohn's disease.