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4-CPPC
Axon 3189
CAS [29553-70-6]
MF C14H9NO6MW 287.22
- Purity:99%
- Soluble in 0.1N NaOH(aq) and DMSO

Description
4-CPPC is the first potent, selective and reversible inhibitor of pro-inflammatory protein macrophage migration inhibitory factor-2 (MIF-2 or D-DT) with a Ki value of 33 μM and an IC50 value of 27 μM. 4-CPPC shows competitive binding with a 13-fold selectivity for human MIF-2 versus human MIF-1.
KEYWORDS: 4-CPPC | supplier | MIF-2 inhibitor | 4CPPC | 4 CPPC | CAS [29553-70-6] | p-Hydroxyphenyl-pyruvate (HPP) | Phenylpyruvate | MIF-2 | Inhibitor | Receptors
| G Pantouris et al. Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry. 2018 Jul 3;57(26):3599-3605. |
| PV Tilstam et al. A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity. J Biol Chem. 2019 Dec 6;294(49):18522-18531. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
4-(3-Carboxyphenyl)pyridine-2,5-dicarboxylic acid
Parent CAS No.
[29553-70-6]


