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- REP 3123 dihydrochloride
- axon medchem|产品目录|代理商|蚂蚁淘原厂直采
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- 蚂蚁淘在线专注海外进口生物试剂原厂进口
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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
FDI 6 - NCGC 00099374
Axon 2384
CAS [313380-27-7]
MF C19H11F4N3OS2MW 437.43
- Purity:99%
- Soluble in DMSO

Description
Inhibitor of the Forkhead box protein M1 transcription factor (IC50 value 22.5 µM for inhibiting FOXM1-DNA binding). FDI6 displaces FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional downregulation. FDI-6 is inactive against the proteasome, and concordance between its biophysical IC50 and cellular GI50 values (22.5 μM and 18.0 μM, respectively) suggests it does not suffer from the off-target effects of thiostrepton.
| M.V. Gormally et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165. |
| G. Marsico et al. Small molecule inhibition of FOXM1: How to bring a novel compound into genomic context. Genomics Data 3 (2015) 19-23. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Cycle RegulationCell Signaling & OncologyEpigeneticsTranscription FactorsFOXM1TF class 3.3.1
Inhibitor of the Forkhead box protein M1 (FOXM1)
Chemical name
3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide
Parent CAS No.
[313380-27-7]


