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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
A 922500
Axon 2059
CAS [959122-11-3]
MF C26H24N2O4MW 428.48
- Purity:98%
- Optical purity:97% d.e.
- Soluble in DMSO

Description
Highly potent and selective diacylglycerol acyltransferase (DGAT) isomer 1 (DGAT-1) inhibitor with nanomolar potency
| G Zhao et al. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J. Med. Chem. 2008, 51(3), 380-383. |
| AJ King et al. Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster. J. Pharmacol. Exp. Ther.2009, 330(2), 526-531. |
| AJ King et al. In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. Eur. J. Pharmacol. 2010, 637(1-3), 155-161. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismDGAT-1EC 2.3.1.20
Highly potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor
Chemical name
(1R,2R)-2-(4"-(3-phenylureido)biphenylcarbonyl)cyclopentanecarboxylic acid
Parent CAS No.
[959122-11-3]


