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商品描述
ProductDescription
TMC207(Bedaquiline)isadiarylquinoline-basedinhibitorofbacterialATPsynthaseatnanomolarconcentrations.InvitromycobacterialexperimentsshowthatTMC207inhibitsdrug-sensitiveanddrug-resistantmycobacterialTBatanMICrangeof2to60nMandanMIC50of30ng/mL.AdditionallyTMC207isbroadlypotentagainstmanynon-tuberculousmycobacteria,withMICsof6to500nM.(1)
StudiesshowthatTMC207isorally-availableandefficaciousonaonce-dailyadmiNISTrationforpatientswithpulmonaryTB.Noseriousadverseeventswereobserved.(2)
Technicalinformation:
| ChemicalFormula: | C32H31BrN2O2 | |
| CAS#: | 843663-66-1 | |
| MolecularWeight: | 555.5 | |
| Purity: | >98% | |
| Appearance: | white | |
| ChemicalName: | (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol | |
| Solubility: | Upto2mMinDMSO | |
| Synonyms: | TMC207,TMC-207,Bedaquiline |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Matteellietal.,TMC207:thefirstcompoudnofanewclassofpotentanti-tuberculosisdrugs.FutureMicrobiol.2010,5(6),849-858.PubmedID:20521931 |
| 2. | Rustomjeeetal.,EarlyBactericidalActivityandPharmacokineticsoftheDiarylquinolineTMC207inTreatmentofPulmonaryTuberculosis.Antimicrob.AgentsChemother.2008,52(8),2831-2835.PubmedID:18505852 |
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