ProductDescription
Cefdinirisanorally-available,b-lactamantibioticthatbindstopenicillin-susceptIBLeStaphylococcusaureus2132atanMICof25nM(1)andE.ColiC11atanMICof63nM(ED50of1.32mg/kg)(2)Incontrasttootheroralcephalosporins,cefdinirretainssubstantialactivityagainstapanelofbacterialstrainsandisfoundtobeextremelystableagainstnumerousb-lactamases.Additionally,cefdinirinhibitstheadherenceoftype-1fimbriatedE.colitouroepithelialcells.(3)
Inclinicalstudies,cefdinirhasbeenshowntobesuperiortopencillinVandcomparabletocephalexinandamoxicillin/clavulanateinthetreatmentofbothpediatricandadultbacterialinfections.(3)
Technicalinformation:
| ChemicalFormula: | C14H13N5O5S2 | |
| CAS#: | 91832-40-5 | |
| MolecularWeight: | 395.41 | |
| Purity: | >98% | |
| Appearance: | white | |
| ChemicalName: | (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azABIcyclo[4.2.0]oct-2-ene-2-carboxylicacid | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | Cefdinir,FK482,CI-983,andPD134393,Omnicef |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Yamaguchietal.,InVitroandInVivoAntibacterialActivitiesofCS-834,aNewOralCarbapenem.Antimicrob.AgentsChemother.1998,42(3),555-563PubmedID:9517932 |
| 2. | Fukuokaetal.,EfficacyofCS-834againstExperimentalPneumoniaCausedbyPenicillin-Susceptibleand-ResistantStreptococcuspneumoniaeinMice.AntimicrobAgentsChemother.1998,42(1),23-27.PubmedID:9449255 |
| 3. | Guayetal.,Cefdinir:AnExpanded-SpectrumOralCephalosporin.AnnalsPharmacother.2000,34,1469-1477.PubmedID:11144705 |
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