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商品描述
ProductDescription
Sitagliptin(alsonamedMK-0431andmarketedasJanuvia)isacompetitiveinhibitoroftheenzymedipeptidylpeptidase4(DPP-4).Sitagliptincanincreaseincretinlevels(GLP-1andGIP),whichinhibitglucagonrelease,whichinturnincreasesinsulinsecretion,decreasesgastricemptying,anddecreasesbloodglucoselevels.
Technicalinformation:
| ChemicalFormula: | C16H15F6N5O | |
| CAS#: | 486460-32-6 | |
| MolecularWeight: | 407.31 | |
| Purity: | >98% | |
| Appearance: | Whitesolid | |
| ChemicalName: | (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one | |
| Solubility: | Upto100mMinDMSO |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storage:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | HermanGA,etal.Pharmacokineticsandpharmacodynamicsofsitagliptin,aninhibitorofdipeptidylpeptidaseIV,inhealthysubjects:resultsfromtworandomized,double-blind,placebo-controlledstudieswithsingleoraldoses.ClinPharmacolTher2005;78(6):675–88. |
| 2. | HermanGA,etal.PharmacokineticsandpharmacodynamiceffectsoftheoralDPP-4inhibitorsitagliptininmiddle-agedobesesubjects.JClinPharmacol2006;46(8):876–86. |
| 3. | LeeB,etal.Pharmacokinetic,pharmacodynamic,andefficacyprofilesofalogliptin,anovelinhibitorofdipeptidylpeptidase-4,inrats,dogs,andmonkeys.EurJPharmacol.2008;589(1-3):306-14 |
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