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商品描述
| Source | M.W. | CAS No. | |||
|---|---|---|---|---|---|
| Structural Info | |||||
| Formulation | Lyophilized in sterile filtered solution of PBS. | ||||
| Reconstitution | Before reconstitution, a brief spin is recommend to drive down anymaterial dislodged from the bottom of the tube. The lyophilized proteinshould be reconstituted in sterile H2O to a desired concentration. | ||||
| Stability | The lyophilized protein is stable for at least one year if stored at -80°C. Reconstituted protein is stable for at least four weeks at 4 °C, butshould be stored in aliquots at -80 °C for longer term. Avoidrepeated freeze and thaw. | ||||
| Purity | Greater than 90% as determined by SDS-PAGE analysis | ||||
| Biological Activity | The activity was determined by using a TCF reporter gene assay in cultured human cells. The EC50 ranges from 2 - 10 ng/ml in the presence of 10 ng/mL human WNT-3a. | ||||
| Country of Origin | USA | ||||
R Spondin-2 is a natural enhancer of the canonical WNT pathway. Whenused together with WNT proteins that activate the beta-catenin pathway, Rspondin-1 enhances the activity of canonical WNT proteins by binding toLGR5 and LGR4 (refs.)Refs: de Lau, et al, LGR5 homologues associate with Wnt receptors and mediate R-spondinsignaling. Nature. 2011 July 4; 476: 293; Carmon, et al, R-spondins function as ligandsfor the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. PNAS.2011 Jul 12; 108: 11452.
Product Sheet
