CNE-CPO (Cationic Nano Emulsion) Vaccine Adjuvant is an oil-in-water Cationic Nano Emulsion made of squalene droplets and cationic polymers in a continuous aqueous phase.

The cationic components that compose this nano-emulsion make it a genetic adjuvant that allows the association with plasmid DNA to form an efficient nanoparticle delivery system (NPD). NPD are non-viral gene delivery systems, self-assembled from cationic entities and negatively charged immunogen that function as vaccine carrier.

CNE-CPO Vaccine Adjuvant is biodegradable, an important advantage over alternative oils that have been used in emulsion adjuvants, like Freund’s adjuvant that contains mineral oil (paraffin oil) and has long term persistence in the organism. CNE induces local stimulation and recruitment of DCs and granulocytes, differentiation of monocytes into DCs and increased uptake of antigen by DCs. The emulsion acts more specifically on macrophages present at the site of injection. A local increase of chemokines released also influences the recruitment of immune cells from the blood to the site of vaccination, creating an amplification loop. This formulation enhances differentiation of monocytes towards a mature phenotype, thereby promoting migration of antigen-loaded cells to the draining lymph node.  

 

Sizes:

•  CNE-CPO is available in two quantities. #CNE1000 1mL; #CNE5000 5mL.

• Also available in bulk, please contact us : order@ozbiosciences.com

Storage: +4°C

Shipping conditions: Room Temperature

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自2003年以来，OZ Biosciences为全球科学界和制药行业创建，开发和生产专门用于转染和转导工具的创新分子递送系统。OZ Biosciences专注于体外和体内应用的生物分子（例如DNA，RNA和蛋白质）的输送技术。在过去的几年中，生命科学经历了技术革命。在基因组学，功能基因组学和蛋白质组学领域所取得的进展为更好地理解基本生物学过程和开发下一代药物创造了绝佳的机会。