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商品描述
Trichostatin APDF
Catalog Number:
E1B1893Amount:
100ugPHYSICAL APPEARANCE: lyophilized solid (m.p.150-151°C)MOLECULAR FORMULA: C17H22N2O3 MOLECULAR WEIGHT: 302.4
Purity:
99% (HPLC)Solubility:
Soluble in DMSO, DMF and ethanolStorage/Stability:
Store solutions at -20°C for up to 1 year.Recommended Dilutions:
Potent, reversible inhibitor of histone deacetylase at nM concentrations, which thereby induces hyperacetylation of histones. Blocks cell cycle at G1. Induces reversion of ras transformed cells to normal morphology. Inhibits IL-2 gene expression in Jurkat cells (IC50 = 73 nM) and induces immunosuppression in a mouse model.References:
1. J. Taunton et al. Science 1996 272 3712. Y. Hoshikawa et al. Exp.Cell Res. 1994 214 1893. M. Futamura et al. Oncogene 1995 10 11194. I. Takahashi et al. Antibiotics 1996 49 453The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.Price:
50$Form of Antibody:
Trichostatin A[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamideCAS NO: 58880-19-6
