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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
LY-294002PI3K InhibitorPDF
Catalog Number:
E1B1737Amount:
PHYSICAL APPEARANCE: Off-white-pale yellow solid (m.p. 182-184°C)MOLECULAR FORMULA: C19H17NO3
Molecular Weight:
307.4Purity:
99% (TLC)Solubility:
Soluble in DMSO (25 mg/ml warm) and ethanol (25 mg/ml warm)Storage/Stability:
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.Recommended Dilutions:
Potent, cell permeable and specific inhibitor of phosphatidylinositol 3- kinase (IC50 = 1.4 μM; purified PI 3-kinase). Does not significantly inhibit PKC, PKA, MAP kinase, S6 kinase, EGFrK, c-src kinase, PI 4-kinase, DAG kinase or rabbit kidney ATPase at concentrations of 50 μM. In intact neutrophils stimulated with fMet-Leu-Phe, LY 294002 completely abolished PI 3-kinase activity at 50 μM without cell toxicity. Also blocked proliferation of cultured rabbit aortic smooth muscle cells without cell death. Induces apoptosis.References:
1 C.J.Vlahos et al. J.Biol.Chem. 1994 269 52412 V.Sanchez Margalet et al. Biochem.Biophys.Res.Commun. 1994 204 4463 T.J.Kovacsovics et al. J.Biol.Chem. 1995 270 113584 R.Yao and G.M.Cooper Science 1995 267 2003The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.Price:
55$
