Diatheva蚂蚁淘在线

Description

Listeria monocytogenes is a facultative intracellular bacterial pathogen that escapes from a host vacuolar compartment and grows rapidly in the cytosol. Listeriolysin O (LLO), one of its major virulence factors, is a secreted pore-forming protein essential for the escape of L. monocytogenes from the vacuole formed upon initial internalization.In addition, LLO influences the levels of intracellular calcium and stimulates phosphoinositide metabolism to favour bacterial entry. It is also a potent aggregator of lipid rafts and suppresses the host immune response. Phagosomal membrane disruption is enhanced by the bacterial phosphatidylinositol-specific and broad-range phospholipases C, PI-PLC (plcA) and PC-PLC (plcB), respectively. Enzymes cooperate with LLO in the lysis of primary and secondary vacuoles.

Additional information

Size	200 µL
Application	Clinical diagnostics\|Life Sciences
Product type	Reagents for research
Reagent type	Antibody
Category	Lysteria monocytogenes
Subcategory	Polyclonal anti LLO antibody
Antibody type	Primary antibody
Immunogen	Recombinant purified Listeriolysin O proteinexpressed in E.coli

Technical information

Accession number	GenBank AAP33758.1
Size	200 µL
Purity	Purified by Protein A affinity Chromatography
Form	Liquid. Supplied in 100mM sodium citrate, 50mM Tris and 0.05% v/v glycerol. Neutral pH.
Shipping/storage conditions	Shipped at 2-8°C. When stored at +4°C the antibody is stable for 18 months. For extended storage up to 24 months, the solution may be frozen at -20°C in working aliquots. Avoid repested freezing and thawing cycles.
Usage	For Laboratory Research Use Only
Source	Rabbit
Specificity	Listeriolysin O from infected specimens
React with	Listeryolisin Ofrom L. monocytogenes
Recommended dilutions	Recommended starting dilutions can vary lot-to-lot. Consult the suggested starting dilutions on the top of the page for lot specific values.

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Datasheet

References

A Novel Role of Listeria monocytogenes Membrane Vesicles in Inhibition of Autophagy and Cell Death	PUBMED ID: 28516064
Cold-Shock Domain Family Proteins (Csps) Are Involved in Regulation of Virulence, Cellular Aggregation, and Flagella-Based Motility in Listeria monocytogenes	PUBMED ID: 29124040

Related products

Rabbit Anti Listeriolysin O affinity purified Cholesterol-dependent cytolysins (CDCs) are produced by a large number of pathogenic gram–positive bacteria. A member of this family, listeriolysin O (LLO), is produced by the intracellular pathogen Listeria monocytogenes. Polyclonal anti Listeriolysin antibody affinity purified is designed for the specific detection of LLO in in infected speciment as an useful tool in the research of Listeria monocytogenes infections.The affinity purification protocol garantees an improvement on the specificsignal	ANT0016
Recombinant Listeriolysin-O (LLO) Recombinant Listeriolysin O (LLO) is a protein produced in E. coli. LLO is a single polypeptide protein composed of 529 residues lacking the secretion signal peptide (1-25 aa).	REP0007
Recombinant p24 BIOTIN Recombinant p24 is a 24 kDa, full-length protein produced in E. coli and conjugated with NHS Biotin	REP0024
Recombinant Listeriolysin-O (LLO) Recombinant Listeriolysin O (LLO) is a protein produced in E. coli. LLO is a single polypeptide protein composed of 529 residues lacking the secretion signal peptide (1-25 aa).	REP0006
Recombinant Listeriolysin-O PEST minus Recombinant Listeriolysin O without PEST sequence and with haemolytic activity is a protein produced in E. coli.LLO is a single polypeptide protein encoded by the hlyA gene and composed of 529 residues. PEST sequence is 19 amino acids peptide located at the protein NH 2-terminus.	REP0022

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Diatheva小鼠抗1,3β葡聚糖（克隆2G8）描述： Diatheva的mAb 2G8在多种真菌疾病模型中均有效，包括阴道和全身念珠菌感染，侵袭性曲霉菌病和新孢子菌。产品类型：一抗单克隆抗体IgG2b亚类免疫原：来自海带的海带与反应： 1,3β-葡聚糖