FOXP3isaforkheadtranscriptionfactorfamilymemberinvolvedinT-cellregulation,activationanddifferentiation.FOXP3hasbeenshowntobeamastercontrolgeneforthedevelopmentandfunctionofCD4+/CD25+regulatoryT-cells.InIHC,FOXP3hasbeenshowntobeaspecificMarkerforadultT-cellleukemia/lymphoma(1).Inmelanomaandinbreastandlungcancers,highnumbersofcirculatingregulatoryTcellshavebeenassociatedwithdiseaseprogression(2-5).Conversely,theinfiltrationofFOXP3+regulatoryTcellsintoinvasivetumorshasalsobeenreportedtobeassociatedwithsurvivalinavarietyofcancers(2-7).Incoloncancers,ahighfrequencyofFOXP3+infiltrateshasshowntobeapositiveindicator(6-7).PatientswithhighFOXP3expressioninCrohn’sdiseasehaveshownabetterresponsetoinfliximabtherapy(8).Inallographyrecipients,FOXP3celllevelsmayalsobeusefulinimprovingpost-transplantmanagement(9).
| ByLetter | F |
|---|---|
| IntendedUse | IVD |
| Format | Concentrate,Predilute |
| Clone | 86D |
| Volume | 0.1ml,1.0ml,6.0ml |
| Isotype | IgG1 |
| Localization | Nucelar |
| PositiveControl | Coloncancerandtonsil |
References:
1.RoncadorG,etal.FOXP3,aselectivemarkerforasubsetofadultT-cellleukaemia/lymphoma.Leukemia.2005Dec;19(12):2247-53.
2.GerberAL,etal.HighexpressionofFOXP3inprimarymelanomaisassociatedwithtumorprogression.BrJDermatol.2014Jan;170(1):103-9.
3.AliHR,etal.AssociationbetweenCD8+T-cellinfiltrationandbreastcancersurvivalin12,439patients.AnnOncol.2014Aug;25(8):1536-43.
4.LiuH,etal.Tumor-infiltratinglymphocytespredictresponsetochemotherapyinpatientswithadvancenon-smallcelllungcancer.CancerImmunolImmunother.2012Oct;61(10):1849-56.
5.TaoH,etal.Densityoftumor-infiltratingFOXP3+TcellsasaresponsemarkerforinductionchemorADIotherapyandapotentialprognosticfactorinpatientstreatedwithtrimodalitytherapyforlocallyadvancednon-smallcelllungcancer.AnnThoracCardiovascSurg.2014;20(6):980-6.
6.LingA,etal.TheintratumouralsubsiteandrelationofCD8(+)andFOXP3(+)Tlymphocytesincolorectalcancerprovideimportantprognosticclues.BrJCancer.2014May13;110(10):2551-9.
7.FreyDM,etal.Highfrequencyoftumor-infiltratingFOXP3(+)regulatoryTcellspredictsimprovedsurvivalinmismatchrepairproficientcolorectalcancerpatients.IntJCancer.2010Jun1;126(11):2635-43.
8.SloanS,etal.FOXP3+regulatoryT-cellcountscorrelatewithhistologicalresponseinCrohn’scolitistreatedwithinfliximab.PatholInt.2014Dec;64(12):624-7.
9.StenardF,etal.DecreasesincirculatingCD4+CD25hiFOXP3+cellsandincreasesinintragraftFOXP3+cellsaccompanyallograftrejectioninpediatricliverallograftrecipients.PediatrTransplant.2009Feb;13(1):70-80.
10.CenterforDiseaseControlManual.Guide:SafetyManagement,NO.CDC-22,Atlanta,GA.April30,1976“DecontaminationofLaboratorySinkDrainstoRemoveAzideSalts.”
11.ClinicalandLaboratoryStandardsInstitute(CLSI).ProtectionofLaboratoryWorkersfromOccupationallyAcquiredInfections;ApprovedGuideline-FourthEditionCLSIdocumentM29-A4Wayne,PA2014.
