CD137,amemberofthetumornecrosisfactorreceptorsuperfamily,representsapromisingtargetforenhancingantitumorimmuneresponses(1).ThefunctionsofCD137inTlymphocytesincluderegulatingactivation,proliferationandapoptosis(2).CD137helpsregulatetheactivationofmanyimmunecells,includingCD4(+)Tcells,CD8(+)Tcells,dendriticcells,andnaturalkillercells.Recentstudiesindicatethattheantitumorefficacyoftherapeutictumor-targetingantibodiescanbeaugmentedbytheadditionofagoNISTicantibodiestargetingCD137.AsligationofCD137providesacostimulatorysignalinmultipleimmunecellsubsets,CD137antibodyhaspotentialtoimprovecancertreatment,andhasbeenimplicatedinbreastcancer,melanomaandlymphoma(3-5).Therefore,CD137agonistsrepresentapromisingimmunotherapeuticapproachtotreatingcancers.
| Format | Concentrate,Predilute |
|---|---|
| Volume | 0.1ml,0.5ml,6.0ml |
| Source | MouseMonoclonal |
| ByLetter | C |
| Antigen | Ectodomainofhuman4-1BBrecombinantprotein |
| Clone | BBK-2 |
| IntendedUse | IVD |
| Isotype | IgG1/kappa |
| Localization | Cellsurface |
| PositiveControl | SmallintestinewithPeyer’spatches,tonsil |
| SpeciesReactivity | Human;othersnottested |
References:
1.YonezawaA,etal.Boostingcancerimmunotherapywithanti-CD137antibodytherapy.ClinCancerRes.2015Jul15;21(14):3113-20.
2.HurtadoJC,etal.Potentialroleof4-1BBinTcellactivation.ComparisonwiththecostimulatorymoleculeCD28.JImmunol.1995Oct1;155(7):3360-7.
3.MartinetO,etal.Tcellactivationwithsystemicagonisticantibodyversuslocal4-1BBligandgenedeliverycombinedwithinterleukin-12erADIcatelivermetastasesofbreastcancer.GeneTher.2002Jun;9(12):786-92.
4.LiSY,LiuY.ImmunotherapyofmelanomawiththeimmunecostimulatorymonoclonalantibodiestargetingCD137.ClinPharmacol.2013Sep2;5(Suppl1):47-53.
5.ZhaoS,etal.CD137ligandisexpressedinprimaryandsecondarylymphoidfolliclesandinB-celllymphomas:diagnosticandtherapeuticimplications.AmJSurgPathol.2013Feb;37(2):250-8.
6.CenterforDiseaseControlManual.Guide:SafetyManagement,NO.CDC-22,Atlanta,GA.April30,1976“DecontaminationofLaboratorySinkDrainstoRemoveAzideSalts.”
7.ClinicalandLaboratoryStandardsInstitute(CLSI).ProtectionofLaboratoryWorkersfromOccupationallyAcquiredInfections;ApprovedGuideline-FourthEditionCLSIdocumentM29-A4Wayne,PA2014.
