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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
Product information "COX-2 (human recombinant)"
Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid (Cay-90010) to PGH2 (Cay-17020). Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus. The His-tag enzyme, which has a Km value for arachidonate of 6.5 µM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme.
| Keywords: | COX2, PTGS2, COX-2, PHS II, PGHS-2, EC=1.14.99.1, PGH synthase 2, Cyclooxygenase-2, Prostaglandin H2 synthase 2, Prostaglandin G/H synthase 2, Prostaglandin-endoperoxide synthase 2 |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 60122-5 |
Properties
| Application: | Enzyme activity |
| Conjugate: | No |
| Purity: | estimated by SDS-PAGE |
Database Information
| KEGG ID : | K11987 | Find alternatives |
| UniProt ID : | P35354 | Find alternatives |
Handling & Safety
| Storage: | -80°C |
| Shipping: | -20°C (International: -80°C) |
Caution Our products are for laboratory research use only: Not for administration to humans!
