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商品描述
Product information "Bafilomycin A1"
Bafilomycin A1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range. It is at least 1,000-fold less potent at most other types of ATPases. Bafilomycin A1 also inhibits autophagy by preventing vacuolar acidification necessary for autophagosome maturation.
| Keywords: | NSC 381866, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 11038-1 |
Properties
| Application: | V-ATPase inhibitor |
| MW: | 622.8 D |
| Formula: | C35H58O9 |
| Purity: | >95% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 88899-55-2| Find alternatives |
| KEGG ID : | K02146 | Find alternatives |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |  |
| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution Our products are for laboratory research use only: Not for administration to humans!
