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| TBBCasein kinase-2 (CK2) inhibitor |
Sample solution is provided at 25 µL, 10mM.
1. Zhao Z, Wang L, et al."Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia." Genes Dev. 2019 Jan1;33(1-2):61-74.PMID:30573454
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- Purity = 98.00%
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| Cas No. | 17374-26-4 | SDF | Download SDF |
| Synonyms | NSC 231634; TBB (enzyme inhibitor);1H-Benzotriazole, 4,5,6,7-tetrabromo- | ||
| Chemical Name | 4,5,6,7-tetrabromo-2H-benzotriazole | ||
| Canonical SMILES | C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br | ||
| Formula | C6HBr4N3 | M.Wt | 434.71 |
| Solubility | ≥159.2 mg/mL in DMSO, ≥10.42 mg/mL in EtOH with ultrasonic, <2.42 mg/ml="" in="" h2o=""> | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.
