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蚂蚁淘在线 / 品牌中心 / pblassaysci / PBL/人干扰素α取样器组/1 x 105units/11002-1

PBL/人干扰素α取样器组/1 x 105units/11002-1

价格
￥43900.00
货号：11002-1
浏览量：127
品牌：pblassaysci
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商品描述

Human IFN Alpha Sampler Set

Home / Products / Proteins / Interferons / Human IFN Proteins / Human IFN Alpha Sampler Set
Product Features:
  • Contains 12 distinct human IFN alpha subtypes for differential activity studies
  • cDNAs of interferons were obtained from human leukocyte mRNA, and expressed in E.coli
  • Provides 100,000 units of IFNa-A, IFNa-B2, IFNa-C, IFNa-D (1[Val114]), IFNa-F, IFNa-G, IFNa-H2, IFNa-I, IFNa-J1, IFNa-K, IFNa-4b, and IFNa-WA (corresponding to IFNa-2a, IFNa-8, IFNa-10, IFNa-1, IFNa-21, IFNa-5, IFNa-14, IFNa-17, IFNa-7, IFNa-6, IFNa-4b, IFNa-16, respectively)

Ordering

Catalog No. Pack Size Price Quantity
11002-1

1 x 105 units

$2,195.00
  • Specifications
  • Tech Info / Data
  • Citations
  • Documentation

Specifications

FormulationIndividual interferons are supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight19.2 -19.7 kDa
SourcecDNA of interferons were obtained from human leukocyte mRNA, and expressed in E.coli
Purity> 95% by SDS-PAGE stained by Coomassie Blue
BioactivityActivities of the interferons are measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)
StorageFor retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cycles
Synonyms

Interferon alpha subtypes, IFN alpha subtypes, IFN-a subtypes, interferon alpha, Leukocyte interferon subtypes, Leukocyte IFN subtypes, alpha interferon subtypes, interferon alfa subtypes, IFN alfa, interferon a, Type I interferon alpha, Type I IFN alpha, Human interferon alpha, IFN-alpha, INF alpha, Human IFN alpha 2a, human IFN alpha 8, human IFN alpha 10, human IFN alpha 1, human IFN alpha 21, human IFN alpha 5, human IFN alpha 14, human IFN alpha 17, human IFN alpha 7, human IFN alpha 6, human IFN alpha 4b, human IFN alpha 16

Accession NumberRefer to CoA

Tech Info / Data

Background:

The Human IFN Alpha Sampler Set provides a collection of 12 distinct biologically active alpha interferons which enables studies of their activity in various applications.

The Human interferon alpha protein family consists of 12 individual protein species, each with reported different biological properties. Some have proven to be 10 and 20 times more effective than Human IFN-alpha A in protecting a cell against specific viruses. Elucidating the functional significances of various IFN-alpha subtypes not only can lead to a better understanding on the role interferons have in an immunological event, but can also lead to the refinement of current interferon based therapeutic applications.

Human IFN Alpha Subtype NomenclatureGene
IFN Alpha AIFN Alpha 2aIFNA2
IFN Alpha 2IFN Alpha 2bIFNA2
IFN Alpha B2IFN Alpha 8IFNA8
IFN Alpha CIFN Alpha 10IFNA10
IFN Alpha D [Val114]IFN Alpha 1IFNA1
IFN Alpha FIFN Alpha 21IFNA21
IFN Alpha GIFN Alpha 5IFNA5
IFN Alpha H2IFN Alpha 14IFNA14
IFN Alpha IIFN Alpha 17IFNA17
IFN Alpha J1IFN Alpha 7IFNA7
IFN Alpha KIFN Alpha 6IFNA6
IFN Alpha 1 [Ala114]IFN Alpha DIFNA1
IFN Alpha 4aIFN Alpha M1IFNA4
IFN Alpha 4bIFN Alpha 4IFNA4
IFN Alpha WAIFN Alpha 16IFNA16

For more information on Human IFN Alpha subtype molecular weight, and theoretical pI click here.

Citations

9 Citations:

  1. Prevost, Jeremie, et al. (2019). Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses. mBio, 18 pgs. PMID: 31213558. (link)

  2. Schlaepfer, et al. (2019). Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects. mSphere, 14 pgs. PMID: 30760614. (link)

  3. Cook, Bradley, et al. (2016). Limited Effects of Type I Interferons on Kyasanur Forest Disease Virus in Cell Culture. PLOS Neglected Tropical Diseases, 19 pgs. PMID: 27479197. (link)

  4. Lavender, Kerry, et al. (2016). Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection in Vivo. JVI, 13 pgs. PMID: 27099312. (link)

  5. Todt, Daniel, et al. (2016). Antiviral Activities of Different Interferon Types and Subtypes Against Hepatitis E Virus Replication. Antimicrobial Agents and Chemotherapy, 8 pgs. PMID: 26787701. (link)

  6. Harper, Michael, et al. (2015). Interferon-alpha Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency, and Effector Mechanisms. PLOS Pathogens, 24 pgs. PMID: 26529416. (link)

  7. Schanen, C, et al. (2006). Correlation Between the Anti-Viral-Induced Cytopathic Effect of Interferon-alpha Subtypes and Induction of MxA Protein In Vitro. Microbiology and Immunology, 19 pgs. PMID: 16428869. (link)

  8. Francois, Catherine, et al. (2005). Quantification of Different Human Alpha Interferon Subtypes and Pegylated Interferon Activities by Measuring MxA Promoter Activation. Antimicrobial Agents and Chemotherapy, 6 pgs. PMID: 16127052. (link)

  9. Sperber, Steven, et al. (1992). Anti-HIV-1 activity of recombinant and hybrid species of interferon-alpha. Journal of Interferon Research, 6 pgs. PMID: 1331260. (link)

References:

For more information on the various alleles of IFN alpha 2a, 2b, 4a, 4b, 1 and D.

  1. Gewart, DR., et al. (1995). J Interferon Cytokine Res. 15 (5):403

  2. Hussain, M., et al. (1997). J Interferon Cytokine Res. 17 (9):559

  3. Hussain, M., et al. (2000). J Interferon Cytokine Res. 20:763

Documentation

PDF icon 11002-1 Certificate of Analysis (CoA)
PDF icon SDS
11002-1 Human IFN Alpha Sampler Set
PBL单克隆抗体和多克隆抗体在某些应用中可以互换。在某些情况下，一种或另一种抗体会产生更好的结果。单克隆抗体在诸如ELISA，流式细胞仪或表位作图等应用中具有很高的特异性，在这些应用中需要特异性结合。多克隆抗体对于中和是优选的，因为它们靶向特定抗原的多种特定表位。 PBL提供了一系列针对来自各种哺乳动物的不同干扰素（IFN）的单克隆和多克隆抗体。与其他市售抗IFN抗体相反，PBL的人IFNα抗体针对多种人IFN亚型进行了测试