PBL/抗人IFNAR2抗体,克隆MMHAR-2,中和(MAb)/50μg/21385-1

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¥9900.00
货号:21385-1
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品牌:pblassaysci
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商品描述

Anti-Human IFNAR2 Antibody, Clone MMHAR-2, neutralizing (MAb)

Product Features:
  • Anti-IFNAR2 antibody (clone MMHAR-2) to human Interferon (Alpha, Beta and Omega) Receptor 2
  • Blocks the biological action of Human Type I Interferons
  • Suitable for use in Type I IFN neutralization, flow cytometry, immunohistochemistry, and immunoprecipitation

Full Product Name: Anti-Human Interferon Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)

Ordering

Catalog No. Pack Size Price Quantity
21385-1

50 μg

$495.00
$575.00
  • Specifications
  • Tech Info / Data
  • Citations
  • Documentation

Specifications

FormulationSupplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
AntigenHuman interferon alpha/beta receptor chain 2 (Human IFNAR2)
IsotypeIgG2A
Host SpeciesMouse
Purity> 95% by SDS-PAGE stained by Coomassie BlueEndotoxin level < 1 EU/μg
BioactivityMeasured by neutralization of interferon in cytopathic effect inhibition assay.
SpecificityNeutralizes human IFN-alpha receptor; interacts with extracellular domain; binds to human IFN-alpha receptor with high affinity; blocks biological action of Type I IFNs
StorageFor retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Antigen SynonymsNone
CloneMMHAR-2

Tech Info / Data

Tested Applications:

  • Neutralization

Suggested Applications*:

  • Immunoprecipitation (1-5 μg/ml)
  • Immunohistochemistry (1 μg/ml)
  • Flow Cytometry (1-10 μg/ml)

*Please note that these applications are presented for suggested use only and have not been fully evaluated by PBL.

 

Background:

The Type I interferon receptor is a heterodimer consisting of IFNAR1 and IFNAR2. The IFNAR2 subunit provides most of the binding affinity for IFN and IFNAR1 is required for optimum signaling.

Citations

Documentation

Neutralization Effect of PBL Anti-Human IFNAR2 Monoclonal Antibody (21385) on Human IFN Alpha 2a (11100) and IFN Beta (11415) Activities in an A549 Cell/EMCV CPE Assay

 

Image depicting PBL Anti-Human IFNAR2 Monoclonal's neutralizing effect on Human IFN Alpha and IFN Beta protection of A549 cells from the cytopathic effect of EMCV infection
PBL单克隆抗体和多克隆抗体在某些应用中可以互换。在某些情况下,一种或另一种抗体会产生更好的结果。单克隆抗体在诸如ELISA,流式细胞仪或表位作图等应用中具有很高的特异性,在这些应用中需要特异性结合。多克隆抗体对于中和是优选的,因为它们靶向特定抗原的多种特定表位。 PBL提供了一系列针对来自各种哺乳动物的不同干扰素(IFN)的单克隆和多克隆抗体。与其他市售抗IFN抗体相反,PBL的人IFNα抗体针对多种人IFN亚型进行了测试